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ChemicalBook CAS DataBase List 1-(O-TOLYL)PIPERAZINE HYDROCHLORIDE
95356-15-3

1-(O-TOLYL)PIPERAZINE HYDROCHLORIDE synthesis

2synthesis methods
-

Yield:95356-15-3 58%

Reaction Conditions:

Stage #1: bis-(2-chloroethyl)amine hydrochloride;o-toluidine in butan-1-ol; for 24 h;Reflux;
Stage #2: with potassium carbonate in butan-1-ol; for 48 h;Reflux;

References:

Zhou, Benhua;Hong, Kwon Ho;Ji, Min;Cai, Jin [Chemical Biology and Drug Design,2018,vol. 92,# 3,p. 1597 - 1609]