ChemicalBook CAS DataBase List 1-HYDROXY-2-NAPHTHALDEHYDE

1-HYDROXY-2-NAPHTHALDEHYDE synthesis

10synthesis methods

Product Name:1-HYDROXY-2-NAPHTHALDEHYDE
CAS Number:574-96-9
Molecular formula:C11H8O2
Molecular Weight:172.18

50-00-0 Synthesis

50-00-0
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$10.00/25g

90-15-3 Synthesis

90-15-3
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$9.00/5g

574-96-9
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$15.00/100mg

Yield: 70%

Reaction Conditions:

Stage #1:α-naphthol with magnesium methanolate at 20; for 0.0166667 h;
Stage #2:formaldehyd at 20; for 0.166667 h;
Stage #3: with sulfuric acid at 20; for 0.166667 h;regioselective reaction;

Steps:

General procedure: A aromatic Phenol 1 (0.1 mol), magnesiummethoxide (5 gr ), and the mixture was grindingto 1 minute at room temperature. A slurry ofparaformaldehyde powder6 (4 gr) in under grindingwas added in small portions over 2 min to thereaction mixture. Stirring was continued at r.t for 8min, after which added slowly to 10% sulfuric acid(20 ml g). The resulting mixture was stirred for 10min, after which the aqueous layer was separatedand extracted with ethyl acetate (2 × 100 ml). Thecombined organic layers and extracts were washedwith 10% sulfuric acid (20 ml) and water (20 ml)and evaporated under reduced pressure to give thesalicyaldehyde 3.

References:

Balali, Ebrahim;Shameli, Abolghasem;Naeimi, Hoseein;MehdiGhanbari, Mohammad [Oriental Journal of Chemistry,2013,vol. 29,# 4,p. 1611 - 1614]

50493-10-2 Synthesis