1-(chloromethyl)-4-methoxy-2-nitrobenzene synthesis

6synthesis methods

Product Name:1-(chloromethyl)-4-methoxy-2-nitrobenzene
CAS Number:101080-02-8
Molecular formula:C8H8ClNO3
Molecular Weight:201.607

75-09-2 Synthesis

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1-(chloromethyl)-4-methoxy-2-nitrobenzene

101080-02-8
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Yield:101080-02-8 86%

Reaction Conditions:

Stage #1: dichloromethanewith n-butyllithium in tetrahydrofuran;hexane at -100; for 0.333333 h;Inert atmosphere;
Stage #2: 3-nitroanisolewith N,N,N,N,-tetramethylethylenediamine in tetrahydrofuran;hexane at -100; for 24 h;Inert atmosphere;
Stage #3: with ammonium chloride in tetrahydrofuran;hexane;water at -100 - 20;Inert atmosphere;

References:

Khutorianskyi, Viktor V.;Klepetá?ová, Blanka;Beier [Organic Letters,2019,vol. 21,# 14,p. 5443 - 5446] Location in patent:supporting information