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ChemicalBook CAS DataBase List 1-Bromo-3-bromomethyl-2-fluorobenzene
149947-16-0

1-Bromo-3-bromomethyl-2-fluorobenzene synthesis

4synthesis methods
261723-32-4 Synthesis
(3-bromo-2-fluorophenyl)methanol

261723-32-4
139 suppliers
$10.00/1g

-

Yield:-

Reaction Conditions:

with dibromotriphenylphosphorane in dichloromethane at 20;

Steps:

2B; 10A

Method 2B: The benzyl alcohol in question was initially charged in dichloromethane (2 ml/mmol), 1.2 eq. of triphenylphosphine dibromide were added and the mixture was stirred at RT overnight. The reaction mixture was then washed with water, and the organic phase was dried over magnesium sulphate and concentrated. The crude product was purified by flash chromatography on silica gel (mobile phase cyclohexane).

References:

US2012/172448,2012,A1 Location in patent:Page/Page column 19-20