ChemicalBook CAS DataBase List 1-BROMO-2,2-DIMETHOXYPROPANE

1-BROMO-2,2-DIMETHOXYPROPANE synthesis

3synthesis methods

Product Name:1-BROMO-2,2-DIMETHOXYPROPANE
CAS Number:126-38-5
Molecular formula:C5H11BrO2
Molecular Weight:183.04

598-31-2
117 suppliers
$60.00/50mg

149-73-5 Synthesis

149-73-5
525 suppliers
$12.00/5g

126-38-5
131 suppliers
$12.00/1g

Yield:126-38-5 87.2%

Reaction Conditions:

with hydrogenchloride in methanol;water at 20; for 2 h;

Steps:

1.2-5.2
S2. Upper protection reaction: Dissolve 30 g of 1-bromoacetone in 13 mL of methanol at room temperature, add 26 g of trimethyl orthoformate and 5.2 g of concentrated hydrochloric acid in sequence, stir and react at room temperature for 2 hours, and TLC detects that the reaction is complete.Adjust the reaction solution to weakly alkaline with a small amount of triethylamine. After removing the trimethyl orthoformate by rotary evaporation, add cold sodium hydroxide methanol solution, extract with dichloromethane, and spin dry the solvent to obtain the product 1-bromo-2 , 2-Dimethoxypropane 35.76g, the yield was 89.2percent.

References:

Beijing Fu Baike Biological Co., Ltd.;Du Chimin CN111348992, 2020, A Location in patent:Page/Page column 4-6

FullText

67-56-1 Synthesis