ChemicalBook CAS DataBase List 1-(BENZYLOXY)-4-BROMO-2-METHOXYBENZENE

1-(BENZYLOXY)-4-BROMO-2-METHOXYBENZENE synthesis

5synthesis methods

Product Name:1-(BENZYLOXY)-4-BROMO-2-METHOXYBENZENE
CAS Number:63057-72-7
Molecular formula:C14H13BrO2
Molecular Weight:293.16

7368-78-7 Synthesis

7368-78-7
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63057-72-7
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Yield: 100%

Reaction Conditions:

with caesium carbonate in acetone for 4 h;Heating / reflux;

Steps:

35 1-Benzyloxy-4-bromo-2-methoxy-benzene
Preparation 35 1-Benzyloxy-4-bromo-2-methoxy-benzene A mixture of 4-bromo-2-methoxyphenol (5 g, 24.63 mmol), benzyl bromide (4.21 g, 24.63 mmol) and cesium carbonate (8 g, 24.63 mmol) in acetone (60 mL) were heated under reflux for 4 hours. The cooled reaction mixture was then evaporated under reduced pressure and the residue was partitioned between diethyl ether (200 mL) and water (80 mL). The aqueous phase was separated and re-extracted with diethyl ether (200 mL). The combined organic extracts were dried over magnesium sulfate and concentrated in vacuo. The residue was azeotroped with dichloromethane to afford the title compound as white solid in 100% yield, 7.19 g. LRMS (ES⁺): m/z [M+Na]⁺ 317

References:

PFIZER INC. US2005/43300, 2005, A1 Location in patent:Page/Page column 39

100-39-0
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2316-64-5 Synthesis