ChemicalBook CAS DataBase List 1,5-Dibromo-2,4-dimethylbenzene

1,5-Dibromo-2,4-dimethylbenzene synthesis

6synthesis methods

Product Name:1,5-Dibromo-2,4-dimethylbenzene
CAS Number:615-87-2
Molecular formula:C8H8Br2
Molecular Weight:263.96

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

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Yield: 48.6%

Reaction Conditions:

Stage #1:m-xylene with iodine for 1 h;Cooling with ice;
Stage #2:bromine

Steps:

1,5-Dibromo-2,4-dimethylbenzene
A 100-mL round bottomed flask wrapped in aluminum foil is charged with m-xylene (40.0 mL, 328 mmol) and iodine (0.48 g, 1.90 mmol). The mixture is stirred for about an hour while cooling in an ice bath. Bromine (34 mL, 656 mmol) is added via dropping funnel over a period of one hour. After overnight reaction, potassium hydroxide (KOH) (20% aq, 150 mL) is added and the resulting mixture is heated gently using a heating mantle. The solid is melted and the biphasic mixture is stirred for about one hour as the yellow color slowly fades. After cooling, the liquid is decanted and the white solid is collected by filtration and washed with additional water (3*100 mL), then recrystallized from ethanol (250 mL). Yield=42.0 g (48.6%)

References:

Dow Global Technologies, LLC;Kuhlman, Roger L.;Whiteker, Gregory T. US8592615, 2013, B2 Location in patent:Sheet 27

108-38-3
357 suppliers
$10.60/50gm:

615-87-2
88 suppliers
$9.00/250mg

References

108-38-3
357 suppliers
$10.60/50gm:

583-70-0 Synthesis