1-(3-Nitorpyridin-2-yl)piperazine synthesis
- Product Name:1-(3-Nitorpyridin-2-yl)piperazine
- CAS Number:87394-48-7
- Molecular formula:C9H12N4O2
- Molecular Weight:208.22
110-85-0
564 suppliers
$5.00/5G
5470-18-8
443 suppliers
$6.00/5g
87394-48-7
68 suppliers
$14.00/100mg
Yield:87394-48-7 95%
Reaction Conditions:
in acetonitrile;Heating / reflux;
Steps:
17.1
Example 17.1: 1 -(3-Nitro-pyridin-2-yl)-piperazine. A mixture of 2-chloro-3-nitro-pyridine (2,0 g, 0.013 mol), piperazine (5.43 g, 0.063 mol) and acetonitrile (50 mL) was heated at reflux overnight. The reaction mixture was cooled to room temperature, diluted with ethyl acetate, washed with water and washed with brine. The organic layer was separated, dried over sodium sulfate, filtered and concentrated to give l-(3-nitro-pyridin-2-yl)-piperazine (2.5 g, 95 %). The product was used without further purification.
References:
WO2008/112440,2008,A1 Location in patent:Page/Page column 38
5470-18-8
443 suppliers
$6.00/5g
142-64-3
190 suppliers
$11.00/25g
87394-48-7
68 suppliers
$14.00/100mg
110-85-0
564 suppliers
$5.00/5G
5470-18-8
443 suppliers
$6.00/5g
87394-48-7
68 suppliers
$14.00/100mg
5086-48-6
10 suppliers
inquiry
504-29-0
550 suppliers
$5.00/5G
87394-48-7
68 suppliers
$14.00/100mg
142-08-5
498 suppliers
$6.00/5g
87394-48-7
68 suppliers
$14.00/100mg