1-(2-NITRO-5-PIPERIDINOPHENYL)-1-ETHANONE synthesis
1synthesis methods
- Product Name:1-(2-NITRO-5-PIPERIDINOPHENYL)-1-ETHANONE
- CAS Number:56915-86-7
- Molecular formula:C13H16N2O3
- Molecular Weight:248.28
Yield:56915-86-7 92.2%
Reaction Conditions:
in N,N-dimethyl-formamide at 110; for 4.5 h;
Steps:
8.1.2. 2-Nitro-5-(4-methylpiperazin-1-yl) acetophenone (3a)
General procedure: The mixture of (2) (13.00 g, 0.065 mol), N-methylpiperazine (19.58 g/21.7 mL, 0.195 mol) and DMF (60 mL) was stirred at 110 °C for 4.5 h and then poured into water (200 mL). The precipitate was collected by filteration and washed using water and petroleum ether to give a yellow powder (13.92 g, 81.22%).
References:
Jiang, Cheng;Yang, Lei;Wu, Wu-Tong;Guo, Qing-Long;You, Qi-Dong [Bioorganic and Medicinal Chemistry,2011,vol. 19,# 18,p. 5612 - 5627] Location in patent:experimental part