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18430-91-6

1-(2-hydroxyphenyl)pentan-1-one synthesis

11synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: potassium carbonate / acetonitrile / 12 h / 20 °C / Inert atmosphere; Reflux
2.1: lithium diisopropyl amide / tetrahydrofuran / 12 h / -78 - 20 °C / Inert atmosphere
2.2: 0.5 h / 0 - 20 °C / Inert atmosphere

References:

Lo, Hong-Jay;Lin, Chin-Yin;Tseng, Mei-Chun;Chein, Rong-Jie [Angewandte Chemie - International Edition,2014,vol. 53,# 34,p. 9026 - 9029][Angew. Chem.,2014,vol. 126,# 34,p. 9172 - 9175,4]