ChemicalBook CAS DataBase List 1-(2-HYDROXYETHYL)-2-METHYLIMIDAZOLE

1-(2-HYDROXYETHYL)-2-METHYLIMIDAZOLE synthesis

12synthesis methods

Product Name:1-(2-HYDROXYETHYL)-2-METHYLIMIDAZOLE
CAS Number:1615-15-2
Molecular formula:C6H10N2O
Molecular Weight:126.16

693-98-1 Synthesis

693-98-1
727 suppliers
$10.00/25g

141-43-5 Synthesis

141-43-5
884 suppliers
$9.00/10g

1615-15-2
75 suppliers
$84.00/250 mg

Yield: 63%

Reaction Conditions:

at 75; for 10 h;Temperature;

Steps:

3
1.3 mol of 2-methylimidazole (2), 1.7 mol of ethanol and 200 ml of nitroethane were added to the reaction vessel equipped with a stirrer, a thermometer and a reflux condenser, and the temperature of the solution was raised to 75C, , Reduce the solution temperature to 55 , standing stratified, remove the lower liquid, dissolved in 1.6L mass fraction of 85% soft eye, reduce the solution temperature to 15 , add the mass fraction of 35% oxalate 130ml, reduce the solution temperature to 4 And filtered, washed with 130ml mass fraction of 75% cyclohexane, recrystallized in mass fraction of 90% acetonitrile, decolorized by molecular sieve, controlled stirring speed 90-110rpm, solidified after 2-3h, washed with potassium bromide solution , The mass fraction was 90% isopropyl alcohol, dehydrated by anhydrous calcium sulfate and dried at 75 to give 126.12g of 1- (β-hydroxyethyl) -2-methylimidazole in 63% yield.

References:

Chengdu qiesite science and technology co ltd;Peng, Fei CN105461631, 2016, A Location in patent:Paragraph 0013; 0014