lubiprostone

$39 - $2020
Product name: lubiprostone
CAS: 333963-40-9
MF: C20H32F2O5
MW: 390.46
EINECS:1312995-182-4
MDL Number:MFCD08444045
Synonyms:(2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-heptanoic acid;Prostan-1-oic acid, 11,15-epoxy-16,16-difluoro-15-hydroxy-9-oxo-, (11alpha,15R)-;Spi 0211;Unii-7662kg2R6k;(2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-h;7-((1R,2R,3R)-2-(4,4-difluoro-3-oxooctyl)-3-hydroxy-5-oxocyclopentyl)heptanoic acid;AMitiza Lubiprostone;7-((2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoic acid

Price9 Properties Safety Information Description

9 prices

Selected condition：

Brand

Alichem
American Custom Chemicals Corporation
AvaChem
Chemenu
Crysdot

Package

5MG
10mg
25mg
100mg
250mg
1g

ManufacturerAlichem
Product number333963409
Product description7-((2R,4AR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoicacid
Packaging250mg
Price$888.8
Updated2021-12-16
Buy

ManufacturerAlichem
Product number333963409
Product description7-((2R,4AR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoicacid
Packaging1g
Price$1979.6
Updated2021-12-16
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ManufacturerAmerican Custom Chemicals Corporation
Product numberAPI0005783
Product descriptionLUBIPROSTONE-D4 95.00%
Packaging5MG
Price$496.11
Updated2021-12-16
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ManufacturerAvaChem
Product number2629
Product descriptionLubiprostone
Packaging100mg
Price$290
Updated2021-12-16
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ManufacturerAvaChem
Product number2629
Product descriptionLubiprostone
Packaging25mg
Price$79
Updated2021-12-16
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ManufacturerAvaChem
Product number2629
Product descriptionLubiprostone
Packaging10mg
Price$59
Updated2021-12-16
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ManufacturerAvaChem
Product number2629
Product descriptionLubiprostone
Packaging5mg
Price$39
Updated2021-12-16
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ManufacturerChemenu
Product numberCM182388
Product description7-((2R,4AR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoicacid 95%+
Packaging1g
Price$1889
Updated2021-12-16
Buy

ManufacturerCrysdot
Product numberCD11142139
Product description7-((2R,4AR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoicacid 97%
Packaging1g
Price$2020
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
Alichem	333963409	7-((2R,4AR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoicacid	250mg	$888.8	2021-12-16	Buy
Alichem	333963409	7-((2R,4AR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoicacid	1g	$1979.6	2021-12-16	Buy
American Custom Chemicals Corporation	API0005783	LUBIPROSTONE-D4 95.00%	5MG	$496.11	2021-12-16	Buy
AvaChem	2629	Lubiprostone	100mg	$290	2021-12-16	Buy
AvaChem	2629	Lubiprostone	25mg	$79	2021-12-16	Buy
AvaChem	2629	Lubiprostone	10mg	$59	2021-12-16	Buy
AvaChem	2629	Lubiprostone	5mg	$39	2021-12-16	Buy
Chemenu	CM182388	7-((2R,4AR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoicacid 95%+	1g	$1889	2021-12-16	Buy
Crysdot	CD11142139	7-((2R,4AR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoicacid 97%	1g	$2020	2021-12-16	Buy

Properties

Boiling point :532.3±50.0 °C(Predicted)
Density :1.175
storage temp. :-20°C Freezer
pka :4.77±0.10(Predicted)

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P304+P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Chronic constipation is an affliction affecting 4–5 million Americans alone. When no specific cause is identified, it is classified as idiopathic. Dietary and lifestyle modifications are the first-line conventional approaches followed by the administration of laxatives. Unfortunately, chronic idiopathic constipation is frequently refractory to traditional therapy; thus, the need for novel agents exists. Lubiprostone is a bicyclic fatty acid with a novel mechanism of action. Without affecting sodium and potassium ion concentrations, lubiprostone activates intestinal chloride ion channels, thereby, increasing intestinal water secretion and intestinal fluid chloride ion concentration. In basolateral membranepermeabilized T84 gastrointestinal epithelial cells under chloride gradient conditions, lubiprostone concentration-dependently increased short-circuit current with an EC50 of approximately 20 nM.

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