Taltirelin
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- $45 - $1957.73
- Product name: Taltirelin
- CAS: 103300-74-9
- MF: C17H23N7O5
- MW: 405.41
- EINECS:
- MDL Number:MFCD00894697
- Synonyms:Taltirelin interMediate;(4S)-Hexahydro-1-Methyl-2,6-dioxo-4-pyriMidinecarbonyl-L-histidyl-;Ceredist, TA-0910;TALTIRELIN INTERMEDIATES;Taltirelin Acetate,TA-0910;Taltirelin;L-Prolinamide, N-[(hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl)carbonyl]-L-histidyl-, (S)-;L-Prolinamide, N-[[(4S)-hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]carbonyl]-L-histidyl- (9CI)
14 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- Biosynth Carbosynth
- Matrix Scientific
- Tocris
- TRC
- Usbiological
Package
- 1
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 1G
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberSHG0007199
- Product descriptionTALTIRELIN 95.00%
- Packaging1G
- Price$1957.73
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT27992
- Product descriptionTaltirelin
- Packaging5mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT27992
- Product descriptionTaltirelin
- Packaging10mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT27992
- Product descriptionTaltirelin
- Packaging25mg
- Price$300
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT27992
- Product descriptionTaltirelin
- Packaging50mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT27992
- Product descriptionTaltirelin
- Packaging100mg
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT27992
- Product descriptionTaltirelin
- Packaging250mg
- Price$750
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT27992
- Product descriptionTaltirelin
- Packaging500mg
- Price$1000
- Updated2021-12-16
- Buy
- ManufacturerMatrix Scientific
- Product number076043
- Product descriptionTaltirelin acetate 95+%
- Packaging1g
- Price$958
- Updated2021-12-16
- Buy
- ManufacturerMatrix Scientific
- Product number076043
- Product descriptionTaltirelin acetate 95+%
- Packaging250mg
- Price$445
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number2672
- Product descriptionTaltirelin ≥96%(HPLC)
- Packaging1
- Price$123
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberT565305
- Product descriptionTaltirelin
- Packaging5mg
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number256806
- Product descriptionTaltirelin
- Packaging1mg
- Price$360
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number289920
- Product descriptionTaltirelin
- Packaging5mg
- Price$418
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | SHG0007199 | TALTIRELIN 95.00% | 1G | $1957.73 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT27992 | Taltirelin | 5mg | $60 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT27992 | Taltirelin | 10mg | $100 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT27992 | Taltirelin | 25mg | $300 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT27992 | Taltirelin | 50mg | $400 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT27992 | Taltirelin | 100mg | $500 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT27992 | Taltirelin | 250mg | $750 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT27992 | Taltirelin | 500mg | $1000 | 2021-12-16 | Buy |
| Matrix Scientific | 076043 | Taltirelin acetate 95+% | 1g | $958 | 2021-12-16 | Buy |
| Matrix Scientific | 076043 | Taltirelin acetate 95+% | 250mg | $445 | 2021-12-16 | Buy |
| Tocris | 2672 | Taltirelin ≥96%(HPLC) | 1 | $123 | 2021-12-16 | Buy |
| TRC | T565305 | Taltirelin | 5mg | $45 | 2021-12-16 | Buy |
| Usbiological | 256806 | Taltirelin | 1mg | $360 | 2021-12-16 | Buy |
| Usbiological | 289920 | Taltirelin | 5mg | $418 | 2021-12-16 | Buy |
Properties
Melting point :72-75°
alpha :25D -13.6° (c = 1 in water)
Density :1.447±0.06 g/cm3(Predicted)
storage temp. :Store at +4°C
form :Solid
pka :9.32±0.40(Predicted)
color :White to off-white
Water Solubility :Soluble to 50 mM in sterile water
alpha :25D -13.6° (c = 1 in water)
Density :1.447±0.06 g/cm3(Predicted)
storage temp. :Store at +4°C
form :Solid
pka :9.32±0.40(Predicted)
color :White to off-white
Water Solubility :Soluble to 50 mM in sterile water
Safety Information
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Description
Taltirelin was marketed in Japan for the treatment of neurodegenerative diseases, in particular the improvement of ataxia due to spino-cerebellar degeneration (SCD); it is the first orally-active drug in this indication. This synthetic thyrotropin-releasing hormone (TRH) analog is prepared by condensation of (S)-1-methyl-4,5-dihydroorotic acid with L-histidyl-Lprolinamide. It was shown that the S-configuration for all 3 chiral centers is crucial for CNS activity. Taltirelin is a potent agonist of the TRH receptors that shows significant effects on the cerebral monoamine systems when administered i.p. in rats. As TRH at 10-fold higher doses, taltirelin has been found to increase the extracellular levels of dopamine and its metabolites (DOPAC and HVA) as well as precursors and/or metabolites of noradrenaline and serotonin in different areas of the rat brain. Taltirelin produced an anti-ataxic activity in the Rolling mouse Nagoya, an ataxic mutant mouse. In several clinical studies performed in patients suffering from various forms of SCD, taltirelin demonstrated a statistically significant increase in the global improvement of ataxic symptoms and other neurologic abnormalities.Related product price
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$33-1920 - Oxytocin
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$71.8-1220
