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ChemicalBook >> CAS DataBase List >> Tadalafil-d3

Tadalafil-d3

Tadalafil-d3 price.
  • $178 - $1963.5
  • Product name: Tadalafil-d3
  • CAS: 960226-55-5
  • MF: C22H18N3O4
  • MW: 388.39602
  • EINECS:
  • MDL Number:MFCD04116200
  • Synonyms:Tadalafil-d3;Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-(methyl-d3)-, (6R,12aR)-;PubChem ID: 46782966;[2H3]-Tadalafil;Tadalafil D3Q: What is Tadalafil D3 Q: What is the CAS Number of Tadalafil D3 Q: What is the storage condition of Tadalafil D3 Q: What are the applications of Tadalafil D3;(2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-(2H?)methyl-3,6,17-triazatetracyclo[8.7.0.03,?.011,1?]heptadeca-1(10),11(16),12,14-tetraene-4,7-dione
5 prices
Selected condition：
Brand
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • TRC
Package
  • 1MG
  • 5mg
  • 10MG
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberRDL0005317
  • Product descriptionTADALAFIL-D3 95.00%
  • Packaging1MG
  • Price$750.75
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberRDL0005317
  • Product descriptionTADALAFIL-D3 95.00%
  • Packaging10MG
  • Price$1963.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number25030
  • Product descriptionTadalafil-d3 ≥99% deuterated forms (d1-d3)
  • Packaging1mg
  • Price$178
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25030
  • Product descriptionTadalafil-d3 ≥99% deuterated forms (d1-d3)
  • Packaging5mg
  • Price$704
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberT004510
  • Product descriptionTadalafil-d3
  • Packaging10mg
  • Price$1390
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation RDL0005317 TADALAFIL-D3 95.00% 1MG $750.75 2021-12-16 Buy
American Custom Chemicals Corporation RDL0005317 TADALAFIL-D3 95.00% 10MG $1963.5 2021-12-16 Buy
Cayman Chemical 25030 Tadalafil-d3 ≥99% deuterated forms (d1-d3) 1mg $178 2024-03-01 Buy
Cayman Chemical 25030 Tadalafil-d3 ≥99% deuterated forms (d1-d3) 5mg $704 2024-03-01 Buy
TRC T004510 Tadalafil-d3 10mg $1390 2021-12-16 Buy

Properties

Melting point :281-283°C
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly), DMSO (Slightly)
form :Solid
color :White to Off-White
Stability :Unstable in Methanol
InChI :InChI=1/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21+/s3
InChIKey :WOXKDUGGOYFFRN-PDIFIXMTNA-N
SMILES :c12c3ccccc3nc1[C@H](c1cc3OCOc3cc1)N1C(=O)CN(C)C(=O)[C@H]1C2 |&1:9,27,r|

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Tadalafil-d3 is intended for use as an internal standard for the quantification of tadalafil by GC- or LC-MS. Tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC50 = 1.2 nM). It is selective for PDE5 over PDE1-4 and 7-10 (IC50s = 9.2-280 μM), however, it does also inhibit PDE11 (IC50 = 11 nM). In vivo, tadalafil (10 mg/kg) decreases production of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 and improves renal function in a rat model of ischemia/reperfusion injury. It also reduces development of tobacco smoke-induced emphysema and pulmonary hypertension in mice. Formulations containing tadalafil have been used to treat erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction.