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ChemicalBook >> CAS DataBase List >> SUFUGOLIX

SUFUGOLIX

SUFUGOLIX price.
  • $36 - $943.91
  • Product name: SUFUGOLIX
  • CAS: 308831-61-0
  • MF: C36H31F2N5O4S
  • MW: 667.72
  • EINECS:
  • MDL Number:MFCD09837896
  • Synonyms:SUFUGOLIX;TAK013;N-(4-(5-((benzyl(methyl)amino)methyl)-1-(2,6-difluorobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl)phenyl)-N'-methoxyurea;TAK013;TAK 013;Sufugolix(TAK-013);SUFUGOLIX, >98%;tak-013, >98%;Urea, N-[4-[1-[(2,6-difluorophenyl)methyl]-1,2,3,4-tetrahydro-5-[[methyl(phenylmethyl)amino]methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-N'-methoxy-
5 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • Cayman Chemical
Package
  • 1mg
  • 5mg
  • 10mg
  • ManufacturerAK Scientific
  • Product number6280CJ
  • Product descriptionSufugolix
  • Packaging5mg
  • Price$260
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberBRS0000770
  • Product descriptionTAK-013 95.00%
  • Packaging5MG
  • Price$943.91
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number27996
  • Product descriptionSufugolix
  • Packaging1mg
  • Price$36
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27996
  • Product descriptionSufugolix
  • Packaging5mg
  • Price$145
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27996
  • Product descriptionSufugolix
  • Packaging10mg
  • Price$223
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 6280CJ Sufugolix 5mg $260 2021-12-16 Buy
American Custom Chemicals Corporation BRS0000770 TAK-013 95.00% 5MG $943.91 2021-12-16 Buy
Cayman Chemical 27996 Sufugolix 1mg $36 2024-03-01 Buy
Cayman Chemical 27996 Sufugolix 5mg $145 2024-03-01 Buy
Cayman Chemical 27996 Sufugolix 10mg $223 2024-03-01 Buy

Properties

Density :1.383±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C,unstable in solution, ready to use.
solubility :DMF: 5mg/mL; DMF:PBS (pH 7.2) (1:2): 0.3mg/mL; DMSO: 3mg/mL
form :A solid
pka :13.20±0.70(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Sufugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist (IC50 = 0.1 nM). Sufugolix inhibits GnRH-induced arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) release in CHO cells expressing human recombinant or monkey recombinant GnRH (IC50s = 0.1 and 10 nM, respectively), but not the rat GnRH receptor. It inhibits luteinizing hormone (LH) release stimulated by GnRH in monkey pituitary cells ex vivo (IC50 = 36 nM). Sufugolix (10 and 30 mg/kg) reduces increases in plasma LH following castration in male cynomolgus monkeys and lowers serum LH, estradiol, and progesterone levels in female cynomolgus monkeys when administered at a dose of 90 mg/kg.

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