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ChemicalBook >> CAS DataBase List >> RAF265(CHIR-265)

RAF265(CHIR-265)

RAF265(CHIR-265) price.
  • $28 - $3136.5
  • Product name: RAF265(CHIR-265)
  • CAS: 927880-90-8
  • MF: C24H16F6N6O
  • MW: 518.41
  • EINECS:-0
  • MDL Number:MFCD16659061
  • Synonyms:RAF265(CHIR-265);RAF265;CHIR-265 or RAF265;1-Methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine;1-methyl-5-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)-N-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazol-2-amine;1-Methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine RAF265 (CHIR-265);RAF 265 1-Methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine;1H-Benzimidazol-2-amine, 1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-
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Brand
  • AK Scientific
  • Alfa Aesar
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Labseeker
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Tocris
  • TRC
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  • 1unit
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100MG
  • 1g
  • 10mM(in 1mL DMSO)
  • 250mg
  • ManufacturerAK Scientific
  • Product numberX7407
  • Product description1-methyl-5-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)-N-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazol-2-amine
  • Packaging50mg
  • Price$1005
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX7407
  • Product description1-methyl-5-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)-N-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazol-2-amine
  • Packaging1mg
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ67037
  • Product descriptionRAF265
  • Packaging10mg
  • Price$567
  • Updated2023-06-20
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ67037
  • Product descriptionRAF265
  • Packaging5mg
  • Price$305
  • Updated2023-06-20
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000079
  • Product descriptionCHIR-265 95.00%
  • Packaging1MG
  • Price$148.05
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000079
  • Product descriptionCHIR-265 95.00%
  • Packaging10MG
  • Price$1006.58
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000079
  • Product descriptionCHIR-265 95.00%
  • Packaging50MG
  • Price$1734.23
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000079
  • Product descriptionCHIR-265 95.00%
  • Packaging100MG
  • Price$2583.16
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA8313
  • Product descriptionRAF265
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA8313
  • Product descriptionRAF265
  • Packaging5mg
  • Price$120
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA8313
  • Product descriptionRAF265
  • Packaging10mM(in 1mL DMSO)
  • Price$155
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA8313
  • Product descriptionRAF265
  • Packaging25mg
  • Price$360
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberCFN60398
  • Product descriptionRAF265(CHIR-265) ≥98%
  • Packaging5mg
  • Price$268
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180818
  • Product descriptionRAF265 (CHIR-265) >98%
  • Packaging100mg
  • Price$838.1
  • Updated2021-12-16
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  • ManufacturerBiorbyt Ltd
  • Product numberorb180818
  • Product descriptionRAF265 (CHIR-265) >98%
  • Packaging250mg
  • Price$1654.1
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180818
  • Product descriptionRAF265 (CHIR-265) >98%
  • Packaging1g
  • Price$3136.5
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7407 1-methyl-5-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)-N-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazol-2-amine 50mg $1005 2021-12-16 Buy
AK Scientific X7407 1-methyl-5-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)-N-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazol-2-amine 1mg $105 2021-12-16 Buy
Alfa Aesar J67037 RAF265 10mg $567 2023-06-20 Buy
Alfa Aesar J67037 RAF265 5mg $305 2023-06-20 Buy
American Custom Chemicals Corporation KIN0000079 CHIR-265 95.00% 1MG $148.05 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000079 CHIR-265 95.00% 10MG $1006.58 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000079 CHIR-265 95.00% 50MG $1734.23 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000079 CHIR-265 95.00% 100MG $2583.16 2021-12-16 Buy
ApexBio Technology A8313 RAF265 1unit $28 2021-12-16 Buy
ApexBio Technology A8313 RAF265 5mg $120 2021-12-16 Buy
ApexBio Technology A8313 RAF265 10mM(in 1mL DMSO) $155 2021-12-16 Buy
ApexBio Technology A8313 RAF265 25mg $360 2021-12-16 Buy
Arctom CFN60398 RAF265(CHIR-265) ≥98% 5mg $268 2021-12-16 Buy
Biorbyt Ltd orb180818 RAF265 (CHIR-265) >98% 100mg $838.1 2021-12-16 Buy
Biorbyt Ltd orb180818 RAF265 (CHIR-265) >98% 250mg $1654.1 2021-12-16 Buy
Biorbyt Ltd orb180818 RAF265 (CHIR-265) >98% 1g $3136.5 2021-12-16 Buy

Properties

Boiling point :667.6±65.0 °C(Predicted)
Density :1.50
storage temp. :Store at -20°C
solubility :≥25.9 mg/mL in DMSO; insoluble in H2O; ≥7.97 mg/mL in EtOH with ultrasonic
pka :9.07±0.27(Predicted)
form :Solid
color :White to khaki
Sensitive :Light Sensitive

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

RAF265 is a dual inhibitor of mutant B-RafV600E and vascular endothelial growth factor receptor 2 (EC50s = 0.14 and 0.19 μM, respectively, in cell-based assays). It can also inhibit wild-type B-Raf, platelet-derived growth factor receptor, colony-stimulating factor 1R, RET, c-KIT, SRC, and STE20 with IC50 values ranging from 20-100 nM. RAF265 can inhibit proliferation of melanoma and colorectal cancer cell lines with active BRAF mutations as well as suppress tumor growth in melanoma xenograft models bearing B-RafV600E mutations.

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