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ChemicalBook >> CAS DataBase List >> PFI3

PFI3

PFI3 price.
  • $32 - $1141
  • Product name: PFI3
  • CAS: 1819363-80-8
  • MF: C19H19N3O2
  • MW: 321.37
  • EINECS:
  • MDL Number:MFCD28100807
  • Synonyms:PFI3;PFI-3;(E)-1-(2-Hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one;(2E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-(2-pyridinyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-2-propen-1-one;PFI3; PFI 3;CS-1803;(2E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]prop-2-en-1-one;2-Propen-1-one, 1-(2-hydroxyphenyl)-3-[(1R,4R)-5-(2-pyridinyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-, (2E)-
24 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • BroadPharm
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
  • 5mg
  • 25mg
  • 100mg
  • 10
  • 1mg
  • 10mg
  • 50mg
  • 10mM(in 1mL DMSO)
  • 250mg
  • ManufacturerAK Scientific
  • Product number1402DY
  • Product description(E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-pyridin-2-yl-2,5-diazabicyclo[2.2.1]heptan-2-yl]prop-2-en-1-one
  • Packaging250mg
  • Price$1141
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number1402DY
  • Product description(E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-pyridin-2-yl-2,5-diazabicyclo[2.2.1]heptan-2-yl]prop-2-en-1-one
  • Packaging50mg
  • Price$388
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number1402DY
  • Product description(E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-pyridin-2-yl-2,5-diazabicyclo[2.2.1]heptan-2-yl]prop-2-en-1-one
  • Packaging10mg
  • Price$208
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7744
  • Product descriptionPFI3
  • Packaging10mM(in 1mL DMSO)
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7744
  • Product descriptionPFI3
  • Packaging10mg
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS563898
  • Product description(E)-1-(2-Hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one ≥99%
  • Packaging5mg
  • Price$64
  • Updated2021-12-16
  • Buy
  • ManufacturerBroadPharm
  • Product numberBP-25372
  • Product descriptionPFI3
  • Packaging10mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerBroadPharm
  • Product numberBP-25372
  • Product descriptionPFI3
  • Packaging25mg
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerBroadPharm
  • Product numberBP-25372
  • Product descriptionPFI3
  • Packaging50mg
  • Price$400
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number15267
  • Product descriptionPFI-3 ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15267
  • Product descriptionPFI-3 ≥98%
  • Packaging5mg
  • Price$93
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15267
  • Product descriptionPFI-3 ≥98%
  • Packaging10mg
  • Price$169
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15267
  • Product descriptionPFI-3 ≥98%
  • Packaging25mg
  • Price$381
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3455
  • Product descriptionPFI-3 98.42%
  • Packaging5mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3455
  • Product descriptionPFI-3 98.42%
  • Packaging10mg
  • Price$163
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3455
  • Product descriptionPFI-3 98.42%
  • Packaging50mg
  • Price$480
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 1402DY (E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-pyridin-2-yl-2,5-diazabicyclo[2.2.1]heptan-2-yl]prop-2-en-1-one 250mg $1141 2021-12-16 Buy
AK Scientific 1402DY (E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-pyridin-2-yl-2,5-diazabicyclo[2.2.1]heptan-2-yl]prop-2-en-1-one 50mg $388 2021-12-16 Buy
AK Scientific 1402DY (E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-pyridin-2-yl-2,5-diazabicyclo[2.2.1]heptan-2-yl]prop-2-en-1-one 10mg $208 2021-12-16 Buy
ApexBio Technology B7744 PFI3 10mM(in 1mL DMSO) $110 2021-12-16 Buy
ApexBio Technology B7744 PFI3 10mg $130 2021-12-16 Buy
Arctom AS563898 (E)-1-(2-Hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one ≥99% 5mg $64 2021-12-16 Buy
BroadPharm BP-25372 PFI3 10mg $160 2021-12-16 Buy
BroadPharm BP-25372 PFI3 25mg $300 2021-12-16 Buy
BroadPharm BP-25372 PFI3 50mg $400 2021-12-16 Buy
Cayman Chemical 15267 PFI-3 ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 15267 PFI-3 ≥98% 5mg $93 2024-03-01 Buy
Cayman Chemical 15267 PFI-3 ≥98% 10mg $169 2024-03-01 Buy
Cayman Chemical 15267 PFI-3 ≥98% 25mg $381 2024-03-01 Buy
ChemScene CS-3455 PFI-3 98.42% 5mg $90 2021-12-16 Buy
ChemScene CS-3455 PFI-3 98.42% 10mg $163 2021-12-16 Buy
ChemScene CS-3455 PFI-3 98.42% 50mg $480 2021-12-16 Buy

Properties

storage temp. :2-8°C
solubility :Soluble in DMSO (>25 mg/ml)
form :powder
color :yellow to orange
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The SWI/SNF-related, Matrix-associated, Actin-dependent Regulator of Chromatin (SMARC) proteins integrate into complexes that remodel chromatin. The SMARC family A (SMARCA) members SMARCA2 (also known as BRM) and SMARCA4 (BRG1) are helicases that contain structurally-related bromodomains for binding acetylated lysine residues on target proteins. The protein polybromo-1 (PB1, BRG1-associated factor) contains six bromodomains, but only the fifth (PB1(5)) shares the same structural signature as those of SMARCA2 and SMARCA4. PFI-3 is a probe that binds avidly to the structurally-similar SMARCA4 bromodomain and PB1(bromodomain 5) with Kd values of 89 and 48 nM, respectively. Evaluation of interactions of PFI-3 with different classes of bromodomains using thermal stability assay indicates that PFI-3 interacts selectively with bromodomains from SMARCA2 and SMARCA4 as well as the fifth domain of PB1. Similarly, PFI-1 does not interact with a panel of kinases. See the Structural Genomics Consortium (SGC) website for more information.

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