PF-3758309
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- $60 - $3728.1
- Product name: PF-3758309
- CAS: 898044-15-0
- MF: C25H30N8OS
- MW: 490.62
- EINECS:
- MDL Number:MFCD18633226
- Synonyms:PF-3758309;(S)-N-(2-(diMethylaMino)-1-phenylethyl)-6,6-diMethyl-3-((2-Methylthieno[3,2-d]pyriMidin-4-yl)aMino)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxaMide;PF-03758309/PF03758309;N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide;PF-03758309;Pyrrolo[3,4-c]pyrazole-5(1H)-carboxaMide, N-[(1S)-2-(diMethylaMino)-1-phenylethyl]-4,6-dihydro-6,6-diMethyl-3-[(2-Methylthieno[3,2-d]pyriMidin-4-yl)aMino]-;N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide PF 3758309;X4Z
21 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
Package
- 25mg
- 100mg
- 250mg
- 1000mg
- 5mg
- 10MG
- 50mg
- 10mM(in 1mL DMSO)
- ManufacturerAK Scientific
- Product number2643AH
- Product descriptionPF-3758309
- Packaging5mg
- Price$128
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000780
- Product descriptionPF-3758309 95.00%
- Packaging10MG
- Price$240.45
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3716
- Product descriptionPF-3758309
- Packaging50mg
- Price$235
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3716
- Product descriptionPF-3758309
- Packaging10mg
- Price$79
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3716
- Product descriptionPF-3758309
- Packaging10mM(in 1mL DMSO)
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180922
- Product descriptionPF-03758309 >98%
- Packaging100mg
- Price$950.3
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180922
- Product descriptionPF-03758309 >98%
- Packaging250mg
- Price$1876.8
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180922
- Product descriptionPF-03758309 >98%
- Packaging1000mg
- Price$3728.1
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19186
- Product descriptionPF-3758309 ≥98%
- Packaging25mg
- Price$239
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19186
- Product descriptionPF-3758309 ≥98%
- Packaging10mg
- Price$104
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19186
- Product descriptionPF-3758309 ≥98%
- Packaging5mg
- Price$62
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM151603
- Product description(S)-N-(2-(Dimethylamino)-1-phenylethyl)-6,6-dimethyl-3-((2-methylthieno[3,2-d]pyrimidin-4-yl)amino)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide 98%
- Packaging100mg
- Price$359
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0773
- Product descriptionPF-3758309 99.95%
- Packaging5mg
- Price$66
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0773
- Product descriptionPF-3758309 99.95%
- Packaging10mg
- Price$96
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0773
- Product descriptionPF-3758309 99.95%
- Packaging50mg
- Price$288
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0773
- Product descriptionPF-3758309 99.95%
- Packaging100mg
- Price$480
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2643AH | PF-3758309 | 5mg | $128 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000780 | PF-3758309 95.00% | 10MG | $240.45 | 2021-12-16 | Buy |
| ApexBio Technology | A3716 | PF-3758309 | 50mg | $235 | 2021-12-16 | Buy |
| ApexBio Technology | A3716 | PF-3758309 | 10mg | $79 | 2021-12-16 | Buy |
| ApexBio Technology | A3716 | PF-3758309 | 10mM(in 1mL DMSO) | $60 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180922 | PF-03758309 >98% | 100mg | $950.3 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180922 | PF-03758309 >98% | 250mg | $1876.8 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180922 | PF-03758309 >98% | 1000mg | $3728.1 | 2021-12-16 | Buy |
| Cayman Chemical | 19186 | PF-3758309 ≥98% | 25mg | $239 | 2024-03-01 | Buy |
| Cayman Chemical | 19186 | PF-3758309 ≥98% | 10mg | $104 | 2024-03-01 | Buy |
| Cayman Chemical | 19186 | PF-3758309 ≥98% | 5mg | $62 | 2024-03-01 | Buy |
| Chemenu | CM151603 | (S)-N-(2-(Dimethylamino)-1-phenylethyl)-6,6-dimethyl-3-((2-methylthieno[3,2-d]pyrimidin-4-yl)amino)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide 98% | 100mg | $359 | 2021-12-16 | Buy |
| ChemScene | CS-0773 | PF-3758309 99.95% | 5mg | $66 | 2021-12-16 | Buy |
| ChemScene | CS-0773 | PF-3758309 99.95% | 10mg | $96 | 2021-12-16 | Buy |
| ChemScene | CS-0773 | PF-3758309 99.95% | 50mg | $288 | 2021-12-16 | Buy |
| ChemScene | CS-0773 | PF-3758309 99.95% | 100mg | $480 | 2021-12-16 | Buy |
Properties
Density :1.325±0.06 g/cm3(Predicted)
storage temp. :-20C
solubility :≥24.53 mg/mL in DMSO; insoluble in H2O; ≥101.4 mg/mL in EtOH with gentle warming and ultrasonic
form :Yellowish-white powder
pka :12.82±0.40(Predicted)
color :White to light yellow
storage temp. :-20C
solubility :≥24.53 mg/mL in DMSO; insoluble in H2O; ≥101.4 mg/mL in EtOH with gentle warming and ultrasonic
form :Yellowish-white powder
pka :12.82±0.40(Predicted)
color :White to light yellow
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
p21-Activated kinases (PAKs) are STE20 serine/threonine kinases that are vital to normal cell function. Binding of various upstream partners to PAKs results in release of an autoinhibitory domain that blocks activity of the kinase domain. PAKs are upregulated in several human cancers and are potential therapeutic targets for cancer intervention. PF-3758309 is an ATP-competitive inhibitor of PAK4, preventing the phosphorylation of the PAK4 substrate GEF-H1 (IC50 = 1.3 nM) and blocking anchorage-independent growth of a panel of tumor cell lines (IC50 = 4.7 nM). It also inhibits the ability of kinase domains from other PAKs to phosphorylate peptide substrates (Kis = 18.1, 17.1, 13.7, 190, and 99 nM for PAKs 5, 6, 1, 2, and 3, respectively). PF-3758309 blocks the growth of multiple human tumor xenografts.More related product prices
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![N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide](https://img.chemicalbook.com/ProductImageEN/2020-1/small/fa88ef0b-eaac-444c-8fd5-01ae34e6aa38.png){kind=small}
