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ChemicalBook >> CAS DataBase List >> NVP-BHG712

NVP-BHG712

NVP-BHG712 price.
  • $23 - $3728.1
  • Product name: NVP-BHG712
  • CAS: 940310-85-0
  • MF: C26H20F3N7O
  • MW: 503.48
  • EINECS:
  • MDL Number:MFCD20272929
  • Synonyms:NVP-BHG712;4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide;4-methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide;NVP-BHG712 4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide;4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluorome;NVP-BHG 712; NVP BHG 712;CS-475;CS-688
37 prices
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Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • Chem-Impex
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Sigma-Aldrich
  • TCI Chemical
  • TRC
  • Usbiological
Package
  • 1mg
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  • 100mg
  • 200mg
  • 250mg
  • 1g
  • 1000mg
  • ManufacturerAK Scientific
  • Product numberX7502
  • Product descriptionNVP-BHG 712
  • Packaging5mg
  • Price$174
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA219560
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+%
  • Packaging1mg
  • Price$23
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA219560
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+%
  • Packaging5mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA219560
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+%
  • Packaging10mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA219560
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+%
  • Packaging25mg
  • Price$127
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA219560
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+%
  • Packaging50mg
  • Price$192
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA219560
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+%
  • Packaging100mg
  • Price$282
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA219560
  • Product description4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+%
  • Packaging250mg
  • Price$470
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000894
  • Product descriptionNVP-BHG 712 99.00%
  • Packaging1MG
  • Price$148.05
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000894
  • Product descriptionNVP-BHG 712 99.00%
  • Packaging5MG
  • Price$502.47
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8683
  • Product descriptionNVP-BHG 712
  • Packaging5mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8683
  • Product descriptionNVP-BHG 712
  • Packaging200mg
  • Price$1500
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181297
  • Product descriptionNVP-BHG 712 >98%
  • Packaging100mg
  • Price$1133.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181297
  • Product descriptionNVP-BHG 712 >98%
  • Packaging250mg
  • Price$2097.8
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181297
  • Product descriptionNVP-BHG 712 >98%
  • Packaging1000mg
  • Price$3728.1
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18489
  • Product descriptionNVP-BHG 712 ≥98%
  • Packaging1mg
  • Price$37
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7502 NVP-BHG 712 5mg $174 2021-12-16 Buy
Ambeed A219560 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+% 1mg $23 2021-12-16 Buy
Ambeed A219560 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+% 5mg $50 2021-12-16 Buy
Ambeed A219560 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+% 10mg $75 2021-12-16 Buy
Ambeed A219560 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+% 25mg $127 2021-12-16 Buy
Ambeed A219560 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+% 50mg $192 2021-12-16 Buy
Ambeed A219560 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+% 100mg $282 2021-12-16 Buy
Ambeed A219560 4-Methyl-3-((1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide 98+% 250mg $470 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000894 NVP-BHG 712 99.00% 1MG $148.05 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000894 NVP-BHG 712 99.00% 5MG $502.47 2021-12-16 Buy
ApexBio Technology A8683 NVP-BHG 712 5mg $85 2021-12-16 Buy
ApexBio Technology A8683 NVP-BHG 712 200mg $1500 2021-12-16 Buy
Biorbyt Ltd orb181297 NVP-BHG 712 >98% 100mg $1133.9 2021-12-16 Buy
Biorbyt Ltd orb181297 NVP-BHG 712 >98% 250mg $2097.8 2021-12-16 Buy
Biorbyt Ltd orb181297 NVP-BHG 712 >98% 1000mg $3728.1 2021-12-16 Buy
Cayman Chemical 18489 NVP-BHG 712 ≥98% 1mg $37 2024-03-01 Buy

Properties

Density :1.41
storage temp. :-20°C
solubility :DMSO: >15mg/mL
form :powder
pka :13.20±0.70(Predicted)
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

The EphB4 receptor tyrosine kinase (cloned from erythropoietin-producing hepatocellular carcinoma) and its ligand ephrinB2 play an important role in embryonic vessel development and vascular remodeling. Signaling from this pair is also involved in tumor angiogenesis. NVP-BHG712 is an orally bioavailable inhibitor of EphB4 kinase autophosphorylation (ED50 = 25 nM). It is selective for EphB4, demonstrating an ED50 value of 4.2 μM at the related VEGFR2 receptor and ED50 values >10 μM against a panel of 40 additional kinases. At 3-30 mg/kg, NVP-BHG712 dose dependently inhibits VEGF-directed vessel formation in an in vivo mouse model of angiogenesis.

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