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ChemicalBook >> CAS DataBase List >> Metolazone

Metolazone

Metolazone price.
  • $32 - $1593.9
  • Product name: Metolazone
  • CAS: 17560-51-9
  • MF: C16H16ClN3O3S
  • MW: 365.83
  • EINECS:241-539-3
  • MDL Number:MFCD00069304
  • Synonyms:s720-22 ;7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide, SR-720-22, Diulo, Metenix, Mykrox, Oldren,;6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo- (9CI);6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl- (8CI);Normelan;Xuret;6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro- 2-methyl-3-(2-methylphenyl)-4-oxo-;METAZOLINE
27 prices
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  • AHH
  • AK Scientific
  • Alfa Aesar
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Sigma-Aldrich
  • TRC
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  • 250mg
  • 1g
  • 5g
  • 10g
  • ManufacturerAHH
  • Product numberAPI-1565
  • Product descriptionMetolazone 98%
  • Packaging10g
  • Price$410
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberH024
  • Product descriptionMetolazone
  • Packaging50mg
  • Price$96
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberH37934
  • Product descriptionMetolazone 97%
  • Packaging1g
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberH37934
  • Product descriptionMetolazone 97%
  • Packaging5g
  • Price$270
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0003352
  • Product descriptionMETOLAZONE 95.00%
  • Packaging100MG
  • Price$704.55
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0003352
  • Product descriptionMETOLAZONE 95.00%
  • Packaging1G
  • Price$1593.9
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1975
  • Product descriptionMetolazone
  • Packaging50mg
  • Price$68
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb134400
  • Product descriptionMetolazone (Zaroxolyn) >99%
  • Packaging100mg
  • Price$510
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb134400
  • Product descriptionMetolazone (Zaroxolyn) >99%
  • Packaging250mg
  • Price$765
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb134400
  • Product descriptionMetolazone (Zaroxolyn) >99%
  • Packaging1g
  • Price$1504.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number15987
  • Product descriptionMetolazone ≥98%
  • Packaging100mg
  • Price$169
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number26304
  • Product descriptionMetolazone
  • Packaging5mg
  • Price$152
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15987
  • Product descriptionMetolazone ≥98%
  • Packaging50mg
  • Price$109
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15987
  • Product descriptionMetolazone ≥98%
  • Packaging25mg
  • Price$60
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number26304
  • Product descriptionMetolazone
  • Packaging1mg
  • Price$57
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15987
  • Product descriptionMetolazone ≥98%
  • Packaging10mg
  • Price$32
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH API-1565 Metolazone 98% 10g $410 2021-12-16 Buy
AK Scientific H024 Metolazone 50mg $96 2021-12-16 Buy
Alfa Aesar H37934 Metolazone 97% 1g $95 2021-12-16 Buy
Alfa Aesar H37934 Metolazone 97% 5g $270 2021-12-16 Buy
American Custom Chemicals Corporation API0003352 METOLAZONE 95.00% 100MG $704.55 2021-12-16 Buy
American Custom Chemicals Corporation API0003352 METOLAZONE 95.00% 1G $1593.9 2021-12-16 Buy
ApexBio Technology B1975 Metolazone 50mg $68 2021-12-16 Buy
Biorbyt Ltd orb134400 Metolazone (Zaroxolyn) >99% 100mg $510 2021-12-16 Buy
Biorbyt Ltd orb134400 Metolazone (Zaroxolyn) >99% 250mg $765 2021-12-16 Buy
Biorbyt Ltd orb134400 Metolazone (Zaroxolyn) >99% 1g $1504.5 2021-12-16 Buy
Cayman Chemical 15987 Metolazone ≥98% 100mg $169 2024-03-01 Buy
Cayman Chemical 26304 Metolazone 5mg $152 2024-03-01 Buy
Cayman Chemical 15987 Metolazone ≥98% 50mg $109 2024-03-01 Buy
Cayman Chemical 15987 Metolazone ≥98% 25mg $60 2024-03-01 Buy
Cayman Chemical 26304 Metolazone 1mg $57 2024-03-01 Buy
Cayman Chemical 15987 Metolazone ≥98% 10mg $32 2024-03-01 Buy

Properties

Melting point :252-254°C
Boiling point :613.6±65.0 °C(Predicted)
Density :1.2895 (rough estimate)
refractive index :1.6100 (estimate)
storage temp. :2-8°C
solubility :DMSO: >5mg/mL
pka :pKa 9.7 (Uncertain)
form :solid
color :white
Water Solubility :60.3mg/L(25 ºC)
Stability :Stable for 2 years as supplied. Solutions in DMSO may be stored desiccated at -20°C for up to 2 months.
InChIKey :AQCHWTWZEMGIFD-UHFFFAOYSA-N
CAS DataBase Reference :17560-51-9(CAS DataBase Reference)
NIST Chemistry Reference :Metolazone(17560-51-9)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

Metolazone is a thiazide-like diuretic that targets the Na+-Cl- cotransporter responsible for salt reabsorption in the distal convoluted tubule of the kidney (IC50 = 0.3 μM in rat). It is also a potent inhibitor of human carbonic anhydrase isoforms VII, XII, and XIII (Kis = 2.1, 5.4, and 15 nM, respectively), which have crucial functions in renal physiology. Metolazone has been predominantly used in the treatment of congestive heart failure and high blood pressure.

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