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ChemicalBook >> CAS DataBase List >> Levosimendan

Levosimendan

Levosimendan price.
  • $11 - $1504.5
  • Product name: Levosimendan
  • CAS: 141505-33-1
  • MF: C14H12N6O
  • MW: 280.28
  • EINECS:663-528-6
  • MDL Number:MFCD00867135
  • Synonyms:R)-((4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrazono) propanedintrile;LEVOSIMENDAN;-2-[[4-(1，4，5，6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)19henyl]hydrazono]Propandinitrile;(R)-Simendan;[[4-[(4R)-1,4,5,6-Terahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazono]propanedinitrile;OR-1259;Simda;Mesoxalonitrile (-)-{p-[(R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl}hydrazone
33 prices
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Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • Chem-Impex
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • TCI Chemical
  • TRC
Package
  • 10MG
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 500mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberF336
  • Product descriptionLevosimendan
  • Packaging250mg
  • Price$210
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA103792
  • Product description(R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)carbonohydrazonoyldicyanide 98+%
  • Packaging25mg
  • Price$11
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA103792
  • Product description(R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)carbonohydrazonoyldicyanide 98+%
  • Packaging100mg
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA103792
  • Product description(R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)carbonohydrazonoyldicyanide 98+%
  • Packaging250mg
  • Price$56
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA103792
  • Product description(R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)carbonohydrazonoyldicyanide 98+%
  • Packaging1g
  • Price$139
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0003165
  • Product descriptionLEVOSIMENDAN 95.00%
  • Packaging25MG
  • Price$411.65
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0003165
  • Product descriptionLEVOSIMENDAN 95.00%
  • Packaging10MG
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0003165
  • Product descriptionLEVOSIMENDAN 95.00%
  • Packaging100MG
  • Price$465
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS427502
  • Product description(R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)carbonohydrazonoyldicyanide ≥98%
  • Packaging25mg
  • Price$11
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS427502
  • Product description(R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)carbonohydrazonoyldicyanide ≥98%
  • Packaging250mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS427502
  • Product description(R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)carbonohydrazonoyldicyanide ≥98%
  • Packaging1g
  • Price$138
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb134373
  • Product descriptionLevosimendan >99%
  • Packaging100mg
  • Price$510
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb134373
  • Product descriptionLevosimendan >99%
  • Packaging1g
  • Price$1504.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBM164625
  • Product descriptionLevosimendan
  • Packaging25mg
  • Price$34
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBM164625
  • Product descriptionLevosimendan
  • Packaging100mg
  • Price$103
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16128
  • Product descriptionLevosimendan ≥98%
  • Packaging50mg
  • Price$57
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific F336 Levosimendan 250mg $210 2021-12-16 Buy
Ambeed A103792 (R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)carbonohydrazonoyldicyanide 98+% 25mg $11 2021-12-16 Buy
Ambeed A103792 (R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)carbonohydrazonoyldicyanide 98+% 100mg $28 2021-12-16 Buy
Ambeed A103792 (R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)carbonohydrazonoyldicyanide 98+% 250mg $56 2021-12-16 Buy
Ambeed A103792 (R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)carbonohydrazonoyldicyanide 98+% 1g $139 2021-12-16 Buy
American Custom Chemicals Corporation API0003165 LEVOSIMENDAN 95.00% 25MG $411.65 2021-12-16 Buy
American Custom Chemicals Corporation API0003165 LEVOSIMENDAN 95.00% 10MG $450 2021-12-16 Buy
American Custom Chemicals Corporation API0003165 LEVOSIMENDAN 95.00% 100MG $465 2021-12-16 Buy
Arctom AS427502 (R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)carbonohydrazonoyldicyanide ≥98% 25mg $11 2021-12-16 Buy
Arctom AS427502 (R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)carbonohydrazonoyldicyanide ≥98% 250mg $55 2021-12-16 Buy
Arctom AS427502 (R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)carbonohydrazonoyldicyanide ≥98% 1g $138 2021-12-16 Buy
Biorbyt Ltd orb134373 Levosimendan >99% 100mg $510 2021-12-16 Buy
Biorbyt Ltd orb134373 Levosimendan >99% 1g $1504.5 2021-12-16 Buy
Biosynth Carbosynth BM164625 Levosimendan 25mg $34 2021-12-16 Buy
Biosynth Carbosynth BM164625 Levosimendan 100mg $103 2021-12-16 Buy
Cayman Chemical 16128 Levosimendan ≥98% 50mg $57 2024-03-01 Buy

Properties

Melting point :216-219°C (dec.)
alpha :D25 -566° (tetrahydrofurane/methanol)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: ≥20mg/mL
form :powder
pka :6.3(at 25℃)
color :yellow
optical activity :[α]/D -500 to -650°, c = 0.5 in THF

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Levosimendan is a calcium sensitizer that can cause increased cardiac contractility by binding troponin C (EC50 = 9 nM), promotes vasodilation by activating ATP-sensitive potassium channels on vascular smooth muscle cells (EC50 = 0.28 μM), and performs a cardioprotective function by prompting the opening of mitochondrial potassium channels in cardiomyocytes. It also has been reported to inhibit phosphodiesterases 3 and 4 in left ventricular cardiac tissue with IC50 values of 2.5 nM and 25 μM, respectively.

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