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ChemicalBook >> CAS DataBase List >> Gilteritinib

Gilteritinib

Gilteritinib price.
  • $32 - $1000
  • Product name: Gilteritinib
  • CAS: 1254053-43-4
  • MF: C29H44N8O3
  • MW: 552.71
  • EINECS:
  • MDL Number:MFCD28144685
  • Synonyms:ASP-2215;2-Pyrazinecarboxamide, 6-ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-;6-Ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide;6-ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide;Gilteritinib (ASP2215);6-Ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-amino)-5-((tetrahydr;ASP2215(Gilteritinib);Gilteritinib(free base)
17 prices
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Brand
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • TRC
  • Usbiological
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • ManufacturerBiosynth Carbosynth
  • Product numberBG166434
  • Product descriptionGilteritinib
  • Packaging10mg
  • Price$145
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBG166434
  • Product descriptionGilteritinib
  • Packaging25mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBG166434
  • Product descriptionGilteritinib
  • Packaging50mg
  • Price$345
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBG166434
  • Product descriptionGilteritinib
  • Packaging100mg
  • Price$540
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBG166434
  • Product descriptionGilteritinib
  • Packaging250mg
  • Price$1000
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number21503
  • Product descriptionGilteritinib ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21503
  • Product descriptionGilteritinib ≥98%
  • Packaging5mg
  • Price$116
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21503
  • Product descriptionGilteritinib ≥98%
  • Packaging10mg
  • Price$214
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21503
  • Product descriptionGilteritinib ≥98%
  • Packaging25mg
  • Price$381
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3885
  • Product descriptionGilteritinib 99.55%
  • Packaging5mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3885
  • Product descriptionGilteritinib 99.55%
  • Packaging10mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3885
  • Product descriptionGilteritinib 99.55%
  • Packaging50mg
  • Price$350
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3885
  • Product descriptionGilteritinib 99.55%
  • Packaging100mg
  • Price$550
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC8164
  • Product descriptionGilteritinib(ASP2215) >98%
  • Packaging100mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC8164
  • Product descriptionGilteritinib(ASP2215) >98%
  • Packaging250mg
  • Price$750
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberG377700
  • Product descriptionGilteritinib
  • Packaging100mg
  • Price$945
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Biosynth Carbosynth BG166434 Gilteritinib 10mg $145 2021-12-16 Buy
Biosynth Carbosynth BG166434 Gilteritinib 25mg $250 2021-12-16 Buy
Biosynth Carbosynth BG166434 Gilteritinib 50mg $345 2021-12-16 Buy
Biosynth Carbosynth BG166434 Gilteritinib 100mg $540 2021-12-16 Buy
Biosynth Carbosynth BG166434 Gilteritinib 250mg $1000 2021-12-16 Buy
Cayman Chemical 21503 Gilteritinib ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 21503 Gilteritinib ≥98% 5mg $116 2024-03-01 Buy
Cayman Chemical 21503 Gilteritinib ≥98% 10mg $214 2024-03-01 Buy
Cayman Chemical 21503 Gilteritinib ≥98% 25mg $381 2024-03-01 Buy
ChemScene CS-3885 Gilteritinib 99.55% 5mg $100 2021-12-16 Buy
ChemScene CS-3885 Gilteritinib 99.55% 10mg $150 2021-12-16 Buy
ChemScene CS-3885 Gilteritinib 99.55% 50mg $350 2021-12-16 Buy
ChemScene CS-3885 Gilteritinib 99.55% 100mg $550 2021-12-16 Buy
DC Chemicals DC8164 Gilteritinib(ASP2215) >98% 100mg $450 2021-12-16 Buy
DC Chemicals DC8164 Gilteritinib(ASP2215) >98% 250mg $750 2021-12-16 Buy
TRC G377700 Gilteritinib 100mg $945 2021-12-16 Buy

Properties

Melting point :>157°C (dec.)
Boiling point :696.9±55.0 °C(Predicted)
Density :1.242±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (25 mg/ml)
form :solid
pka :14.39±0.50(Predicted)
color :Off-white to pale pink
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Gilteritinib is an inhibitor of FMS-related tyrosine kinase 3 (FLT3; IC50 = 5 nM for the wild-type enzyme). It inhibits mutant forms of FLT3, including FLT3 with the internal tandem duplication mutation (FLT3-ITD), FLT3-ITD expressing the F691L mutation, and FLT3 with various tyrosine kinase domain mutations (FLT3-TKD; IC50s =1.4-1.8, 12.2, and 0.7-2 nM, respectively). Gilteritinib also inhibits Axl and c-Kit with IC50 values of 41 and 102 nM, respectively. It decreases the viability of blast cells isolated from patients with relapsed acute myeloid leukemia (AML) in a concentration-dependent manner. Formulations containing gilteritinib have been used in the treatment of AML.

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