GSK-3BETA INHIBITOR XII
|
- $37 - $2395.3
- Product name: GSK-3BETA INHIBITOR XII
- CAS: 601514-19-6
- MF: C18H14N4O2
- MW: 318.33
- EINECS:
- MDL Number:MFCD09037535
- Synonyms:TWS119;GSK-3BETA INHIBITOR XII;3-[6-(3-AMINO-PHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YLOXY]-PHENOL;OTAVA-BB 7070707013;3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxyphenolditrifluoroacetate;3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol TWS 119;TWS 119 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol;GSK-3β Inhibitor, TWS119
28 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Sigma-Aldrich
- Tocris
- Usbiological
Package
- 10
- 1mg
- 2mg
- 5MG
- 10mg
- 25mg
- 50mg
- 2x25mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberX7612
- Product descriptionTWS119
- Packaging50mg
- Price$309
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000114
- Product descriptionGSK-3B INHIBITOR (XII) 95.00%
- Packaging5MG
- Price$499.26
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1540
- Product descriptionTWS119
- Packaging10mg
- Price$85
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60359
- Product descriptionTWS119 ≥98%
- Packaging10mg
- Price$168
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1562
- Product descriptionTWS119 99%
- Packaging25mg
- Price$401.5
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1562
- Product descriptionTWS119 99%
- Packaging2x25mg
- Price$594
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146077
- Product descriptionTWS119 >98%
- Packaging100mg
- Price$615.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146077
- Product descriptionTWS119 >98%
- Packaging250mg
- Price$1208.7
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146077
- Product descriptionTWS119 >98%
- Packaging1g
- Price$2395.3
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA43375
- Product description3-(6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenol
- Packaging1mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA43375
- Product description3-(6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenol
- Packaging2mg
- Price$96
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA43375
- Product description3-(6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenol
- Packaging5mg
- Price$185
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA43375
- Product description3-(6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenol
- Packaging10mg
- Price$320
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA43375
- Product description3-(6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenol
- Packaging25mg
- Price$670
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number10011251
- Product descriptionTWS119 ≥90%
- Packaging1mg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10011251
- Product descriptionTWS119 ≥90%
- Packaging5mg
- Price$90
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7612 | TWS119 | 50mg | $309 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000114 | GSK-3B INHIBITOR (XII) 95.00% | 5MG | $499.26 | 2021-12-16 | Buy |
| ApexBio Technology | B1540 | TWS119 | 10mg | $85 | 2021-12-16 | Buy |
| Arctom | CFN60359 | TWS119 ≥98% | 10mg | $168 | 2021-12-16 | Buy |
| Axon Medchem | Axon1562 | TWS119 99% | 25mg | $401.5 | 2021-12-16 | Buy |
| Axon Medchem | Axon1562 | TWS119 99% | 2x25mg | $594 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146077 | TWS119 >98% | 100mg | $615.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146077 | TWS119 >98% | 250mg | $1208.7 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146077 | TWS119 >98% | 1g | $2395.3 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA43375 | 3-(6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenol | 1mg | $60 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA43375 | 3-(6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenol | 2mg | $96 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA43375 | 3-(6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenol | 5mg | $185 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA43375 | 3-(6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenol | 10mg | $320 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA43375 | 3-(6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenol | 25mg | $670 | 2021-12-16 | Buy |
| Cayman Chemical | 10011251 | TWS119 ≥90% | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 10011251 | TWS119 ≥90% | 5mg | $90 | 2024-03-01 | Buy |
Properties
Melting point :249 °C
Density :1.42
storage temp. :2-8°C
solubility :insoluble in H2O; insoluble in EtOH; ≥15.9 mg/mL in DMSO
form :powder
pka :8.99±0.10(Predicted)
color :white to beige
Density :1.42
storage temp. :2-8°C
solubility :insoluble in H2O; insoluble in EtOH; ≥15.9 mg/mL in DMSO
form :powder
pka :8.99±0.10(Predicted)
color :white to beige
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||
| Precautionary statements: |
|
Description
GSK-3β Inhibitor XII, TWS119 is a cell-permeable pyrrolopyrimidine compound that has been shown to act as a potent inhibitor of GSK-3β (IC50 = 30 nM). In addition, GSK-3β Inhibitor XII, TWS119 is thought to bind GSK-3β with high-affinity (Kd = 126 nM) and increases the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. This activity has been shown to selectively induce neuronal differentiation in both embryonic stem cells (D3; 50-60% at 400 nM) and pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1μM). As result of GSK-3β Inhibitor XII, TWS119 T cell-specific killing and IFN-g release are reduced via preservation of IL-2 production.Related product price
Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
Hubei xin bonus chemical co. LTD
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
Henan Alfa Chemical Co., Ltd
