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ChemicalBook >> CAS DataBase List >> Febuxostat-d9

Febuxostat-d9

Febuxostat-d9 price.
  • $160 - $471
  • Product name: Febuxostat-d9
  • CAS: 1246819-50-0
  • MF: C16H16N2O3S
  • MW: 316.37484
  • EINECS:
  • MDL Number:MFCD21363615
  • Synonyms:Febuxostat-d9;2-(3-Cyano-4-isobutyloxyphenyl-d9)-4-Methyl-5-thiazolecarboxylic Acid;2-[3-Cyano-4-(2-Methylpropoxy-d9)phenyl]-4-Methyl-5-thiazolecarboxylic Acid;TEI 6720-d9;TMX 67-d9;[2H9]-Febuxostat;Febuxostat-d9 (2-methylpropoxy-d9);Febuxostat D9Q: What is Febuxostat D9 Q: What is the CAS Number of Febuxostat D9 Q: What is the storage condition of Febuxostat D9 Q: What are the applications of Febuxostat D9
4 prices
Selected condition:
Brand
  • aablocks
  • AK Scientific
  • Cayman Chemical
  • TRC
Package
  • 1mg
  • Manufactureraablocks
  • Product numberAA009CF5
  • Product descriptionFebuxostat-d9 ≥99%deuteratedforms(d1-d9)
  • Packaging1mg
  • Price$394
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3669AH
  • Product descriptionFebuxostat-D9
  • Packaging1mg
  • Price$471
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number25033
  • Product descriptionFebuxostat-d9 ≥99% deuterated forms (d1-d9)
  • Packaging1mg
  • Price$261
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberF229002
  • Product descriptionFebuxostat-d9
  • Packaging1mg
  • Price$160
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA009CF5 Febuxostat-d9 ≥99%deuteratedforms(d1-d9) 1mg $394 2021-12-16 Buy
AK Scientific 3669AH Febuxostat-D9 1mg $471 2021-12-16 Buy
Cayman Chemical 25033 Febuxostat-d9 ≥99% deuterated forms (d1-d9) 1mg $261 2024-03-01 Buy
TRC F229002 Febuxostat-d9 1mg $160 2021-12-16 Buy

Properties

Melting point :>201°C (dec.)
storage temp. :Refrigerator
solubility :Chloroform (Slightly), Methanol (Slightly)
form :Solid
color :White to Off-White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

Febuxostat-d9 is intended for use as an internal standard for the quantification of febuxostat by GC- or LC-MS. Febuxostat is an antihyperuricemic nonpurine inhibitor of both the oxidized and reduced forms of xanthine oxidase. It inhibits bovine milk xanthine oxidase as well as mouse and rat liver xanthine oxidase/xanthine dehydrogenase (IC50s = 1.4, 1.8, and 2.2 nM, respectively). It is 10-30 times more potent than the hypoxanthine analog allopurinol (; Kis = 0.7 nM and 0.7 μM, respectively). Febuxostat decreases the serum level of urate in a potassium oxonate rat model of hyperuricemia (ED50 = 1.5 mg/kg). It reduces hepatic macrovesicular steatosis in mice fed a high-fat diet containing trans fatty acids when administered at a dose of 1 mg/kg per day. Febuxostat (0.75 mg/kg) also increases CNS expression of glutamate oxaloacetate transaminase 2 (GOT2) and improves neurological symptoms in a mouse model of secondary progressive experimental autoimmune encephalomyelitis (EAE). Formulations containing febuxostat have been used in the treatment of symptomatic hyperuricemia in patients with gout.