EPOXOMICIN
|
- $28 - $1800
- Product name: EPOXOMICIN
- CAS: 134381-21-8
- MF: C28H50N4O7
- MW: 554.72
- EINECS:
- MDL Number:MFCD03791061
- Synonyms:BU-4061T;EPOXOMICIN, SYNTHETIC;EPOXOMICIN;(2R)-2-[ACETYL-(N-METHYL-L-ISOLEUCYL)-L-ISOLEUCYL-L-THREONYL-L-LEUCYL]-2-METHYLOXIRANE;n-acetyl-n-methyl-l-isoleucyl-l-isoleucyl-n-[(1s)-3-methyl-1-[[(2r)-2-methyloxiranyl]carbonyl]butyl]-l-threoninamide;Aids010837;Aids-010837;L-Threoninamide, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-
26 prices
Selected condition：
Brand
- Adipogen Life Sciences
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Usbiological
Package
- 10mM(in 1mL DMSO)
- 25μg
- 50ug
- 50μg
- 100ug
- 100μg
- 250μg
- 1unit
- 1MG
- 5MG
- 10mg
- 20mg
- 50mg
- 250mg
- ManufacturerAdipogen Life Sciences
- Product numberAG-CN2-0422-C100
- Product descriptionEpoxomicin ≥97%(NMR)
- Packaging100μg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000088
- Product descriptionEPOXOMICIN 95.00%
- Packaging1MG
- Price$224.7
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000088
- Product descriptionEPOXOMICIN 95.00%
- Packaging5MG
- Price$498.17
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA2606
- Product descriptionEpoxomicin
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA2606
- Product descriptionEpoxomicin
- Packaging1mg
- Price$135
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA2606
- Product descriptionEpoxomicin
- Packaging5mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA2606
- Product descriptionEpoxomicin
- Packaging10mM(in 1mL DMSO)
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA2606
- Product descriptionEpoxomicin
- Packaging20mg
- Price$1200
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545892
- Product descriptionEpoxomicin >98%
- Packaging100μg
- Price$299.2
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number10007806
- Product descriptionEpoxomicin ≥98%
- Packaging25μg
- Price$63
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10007806
- Product descriptionEpoxomicin ≥98%
- Packaging50μg
- Price$117
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10007806
- Product descriptionEpoxomicin ≥98%
- Packaging100μg
- Price$220
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10007806
- Product descriptionEpoxomicin ≥98%
- Packaging250μg
- Price$486
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-3998
- Product descriptionEpoxomicin 98.81%
- Packaging100ug
- Price$96
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3998
- Product descriptionEpoxomicin 98.81%
- Packaging1mg
- Price$156
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3998
- Product descriptionEpoxomicin 98.81%
- Packaging5mg
- Price$480
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CN2-0422-C100 | Epoxomicin ≥97%(NMR) | 100μg | $120 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000088 | EPOXOMICIN 95.00% | 1MG | $224.7 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000088 | EPOXOMICIN 95.00% | 5MG | $498.17 | 2021-12-16 | Buy |
| ApexBio Technology | A2606 | Epoxomicin | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A2606 | Epoxomicin | 1mg | $135 | 2021-12-16 | Buy |
| ApexBio Technology | A2606 | Epoxomicin | 5mg | $400 | 2021-12-16 | Buy |
| ApexBio Technology | A2606 | Epoxomicin | 10mM(in 1mL DMSO) | $500 | 2021-12-16 | Buy |
| ApexBio Technology | A2606 | Epoxomicin | 20mg | $1200 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb545892 | Epoxomicin >98% | 100μg | $299.2 | 2021-12-16 | Buy |
| Cayman Chemical | 10007806 | Epoxomicin ≥98% | 25μg | $63 | 2024-03-01 | Buy |
| Cayman Chemical | 10007806 | Epoxomicin ≥98% | 50μg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 10007806 | Epoxomicin ≥98% | 100μg | $220 | 2024-03-01 | Buy |
| Cayman Chemical | 10007806 | Epoxomicin ≥98% | 250μg | $486 | 2024-03-01 | Buy |
| ChemScene | CS-3998 | Epoxomicin 98.81% | 100ug | $96 | 2021-12-16 | Buy |
| ChemScene | CS-3998 | Epoxomicin 98.81% | 1mg | $156 | 2021-12-16 | Buy |
| ChemScene | CS-3998 | Epoxomicin 98.81% | 5mg | $480 | 2021-12-16 | Buy |
Properties
Melting point :107-109°
alpha :D24.5 -66.1 ± 0.4° (c = 0.5 in MeOH)
Boiling point :795.7±60.0 °C(Predicted)
Density :1.117±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 10 mg/ml).
pka :13.02±0.46(Predicted)
form :solid
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChIKey :DOGIDQKFVLKMLQ-JTHVHQAWSA-N
alpha :D24.5 -66.1 ± 0.4° (c = 0.5 in MeOH)
Boiling point :795.7±60.0 °C(Predicted)
Density :1.117±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 10 mg/ml).
pka :13.02±0.46(Predicted)
form :solid
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChIKey :DOGIDQKFVLKMLQ-JTHVHQAWSA-N
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
Epoxomicin is a potent proteasome inhibitor, primarily inhibiting the activity of CTRL(chymotrypsin-like proteasome). The novel α-epoxy ketone moiety of Epoxomicin forms covalent bonds with residues in particular catalytic subunits of the enzyme, disabling activity. The trypsin-like and peptidyl-glutamyl peptide hydrolyzing behavior of the proteasome were both inhibited by Epoxomicin as well (at 100 and 1,000-fold slower rates, respectively). Bone formation is heavily regulated by the ubiquitin-proteasome pathway, and Epoxomicin was shown to increase both bone volume and bone formation rates in rodents. Another study demonstrates that exposure to Epoxomicin and other proteasome inhibitors leads to dopaminergic cell death, producing a model of Parkinson's disease in vivo. Epoxomicin is an inhibitor of 20S Proteasome.Related product price
- Ginkgolide B
$32-2355.15 - Zafirlukast
$12-1593.9 - PF-622
$25-997
