Defactinib
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- $37 - $1500
- Product name: Defactinib
- CAS: 1073154-85-4
- MF: C20H21F3N8O3S
- MW: 510.49
- EINECS:
- MDL Number:
- Synonyms:Defactinib;VS 6063;VS-6063;Defactinib(PF-04554878);N-methyl-4-(4-((3-(N-methylmethan-3-ylsulfonamido)pyrazin-2-yl)methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzamide;N-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide;N-METHYL-4-(4-((3-(N-METHYLMETHYL SULFON;N-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide
23 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- TRC
- Usbiological
Package
- 1mg
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberSYN5745
- Product descriptionDefactinib
- Packaging50mg
- Price$617
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0045865
- Product descriptionPF-04554878 95.00%
- Packaging5MG
- Price$505.87
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4800
- Product descriptionDefactinib
- Packaging50mg
- Price$340
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4800
- Product descriptionDefactinib
- Packaging100mg
- Price$410
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2574
- Product descriptionDefactinib-VS6063|PF04554878 98%
- Packaging25mg
- Price$368.5
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD103987
- Product descriptionDefactinib
- Packaging10mg
- Price$300
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17737
- Product descriptionDefactinib ≥98%
- Packaging1mg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17737
- Product descriptionDefactinib ≥98%
- Packaging5mg
- Price$116
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17737
- Product descriptionDefactinib ≥98%
- Packaging10mg
- Price$213
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17737
- Product descriptionDefactinib ≥98%
- Packaging25mg
- Price$353
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM167671
- Product descriptionN-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide 98%
- Packaging100mg
- Price$360
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3410
- Product descriptionDefactinib 99.87%
- Packaging5mg
- Price$84
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3410
- Product descriptionDefactinib 99.87%
- Packaging10mg
- Price$108
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3410
- Product descriptionDefactinib 99.87%
- Packaging50mg
- Price$300
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3410
- Product descriptionDefactinib 99.87%
- Packaging100mg
- Price$420
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3410
- Product descriptionDefactinib 99.87%
- Packaging200mg
- Price$720
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5745 | Defactinib | 50mg | $617 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0045865 | PF-04554878 95.00% | 5MG | $505.87 | 2021-12-16 | Buy |
| ApexBio Technology | B4800 | Defactinib | 50mg | $340 | 2021-12-16 | Buy |
| ApexBio Technology | B4800 | Defactinib | 100mg | $410 | 2021-12-16 | Buy |
| Axon Medchem | Axon2574 | Defactinib-VS6063|PF04554878 98% | 25mg | $368.5 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD103987 | Defactinib | 10mg | $300 | 2021-12-16 | Buy |
| Cayman Chemical | 17737 | Defactinib ≥98% | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 17737 | Defactinib ≥98% | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 17737 | Defactinib ≥98% | 10mg | $213 | 2024-03-01 | Buy |
| Cayman Chemical | 17737 | Defactinib ≥98% | 25mg | $353 | 2024-03-01 | Buy |
| Chemenu | CM167671 | N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide 98% | 100mg | $360 | 2021-12-16 | Buy |
| ChemScene | CS-3410 | Defactinib 99.87% | 5mg | $84 | 2021-12-16 | Buy |
| ChemScene | CS-3410 | Defactinib 99.87% | 10mg | $108 | 2021-12-16 | Buy |
| ChemScene | CS-3410 | Defactinib 99.87% | 50mg | $300 | 2021-12-16 | Buy |
| ChemScene | CS-3410 | Defactinib 99.87% | 100mg | $420 | 2021-12-16 | Buy |
| ChemScene | CS-3410 | Defactinib 99.87% | 200mg | $720 | 2021-12-16 | Buy |
Properties
Density :1.495±0.06 g/cm3(Predicted)
storage temp. :-20°C (des.)
solubility :Soluble in DMSO (up to at least 25mg/ml)
pka :15.16±0.46(Predicted)
form :solid
color :White
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
storage temp. :-20°C (des.)
solubility :Soluble in DMSO (up to at least 25mg/ml)
pka :15.16±0.46(Predicted)
form :solid
color :White
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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| Signal word: | Warning | |||||||
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Description
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays a vital role in many oncogenic pathways. Defactinib is a dose-dependent inhibitor of FAK, with maximal inhibition of FAK autophosphorylation in cells achieved at 10 μM. It is less effective against the related kinase Pyk2. Defactinib restores the chemosensitivity of taxane-resistant cells to paclitaxel , although it is not cytotoxic alone. Defactinib decreases YB-1 phosphorylation and nuclear accumulation in an Akt-dependent manner. It is orally bioavailable, inhibiting FAK and augmenting paclitaxel action in suppressing the growth and number of ovarian cancer cell tumors in mice.More related product prices
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