Debromo Hymenialdisine
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- $110 - $645
- Product name: Debromo Hymenialdisine
- CAS: 75593-17-8
- MF: C11H10N5O2
- MW: 244.2294
- EINECS:
- MDL Number:MFCD04037016
- Synonyms:DEBROMOHYMENIALDISINE;Debromohymenialdesine;Pyrrolo[2,3-c]azepin-8(1H)-one, 4-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-4,5,6,7-tetrahydro-, (4Z)-
5 prices
Selected condition：
Brand
- Adipogen Life Sciences
- Cayman Chemical
- TRC
- Usbiological
Package
- 100ug
- 100μg
- 1mg
- 2.5mg
- ManufacturerAdipogen Life Sciences
- Product numberAG-CN2-0068-C100
- Product descriptionDebromohymenialdisine ≥95%(HPLC)
- Packaging100μg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number14873
- Product descriptionDebromohymenialdisine ≥95%
- Packaging100μg
- Price$110
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberD208900
- Product descriptionDebromoHymenialdisine
- Packaging2.5mg
- Price$645
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number044726
- Product descriptionDebromohymenialdisine
- Packaging100ug
- Price$329
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number007589
- Product descriptionDebromo Hymenialdisine
- Packaging1mg
- Price$623
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CN2-0068-C100 | Debromohymenialdisine ≥95%(HPLC) | 100μg | $110 | 2021-12-16 | Buy |
| Cayman Chemical | 14873 | Debromohymenialdisine ≥95% | 100μg | $110 | 2024-03-01 | Buy |
| TRC | D208900 | DebromoHymenialdisine | 2.5mg | $645 | 2021-12-16 | Buy |
| Usbiological | 044726 | Debromohymenialdisine | 100ug | $329 | 2021-12-16 | Buy |
| Usbiological | 007589 | Debromo Hymenialdisine | 1mg | $623 | 2021-12-16 | Buy |
Properties
Melting point :>250°C (dec.)
storage temp. :-20°C Freezer, Under Inert Atmosphere
solubility :DMSO, Methanol
form :Yellow solid.
color :Yellow
storage temp. :-20°C Freezer, Under Inert Atmosphere
solubility :DMSO, Methanol
form :Yellow solid.
color :Yellow
Safety Information
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Description
Damaged DNA in humans is detected by sensor proteins that transmit a signal through checkpoint kinases (Chks) Chk1 and Chk2. Debromohymenialdisine (DBH) is a marine sponge alkaloid that inhibits Chk1 and Chk2 (IC50 = 3 and 3.5 μM, respectively), blocking G2 arrest. Because it does not significantly affect the activity of ataxia-telangiectasia mutated (ATM) or ATM-Tad2-related protein, DBH is a useful tool for studying the roles of Chk1 and Chk2 in DNA repair and cell cycle regulation. DBH also inhibits MAP kinase kinase 1 (IC50 = 881 nM), glycogen synthase kinase 3β (IC50 = 1.39 μM), cyclin-dependent kinase 5/p25 (IC50 = 9.12 μM), protein tyrosine kinase 6 (IC50 = 0.6 μM), and other kinases largely unrelated to DNA damage/repair and cell cycling.More related product prices
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