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ChemicalBook >> CAS DataBase List >> Bilastine

Bilastine

Bilastine price.
  • $6 - $2310
  • Product name: Bilastine
  • CAS: 202189-78-4
  • MF: C28H37N3O3
  • MW: 463.62
  • EINECS:
  • MDL Number:MFCD09837814
  • Synonyms:4-[2-[4-[1-(2-Ethoxyethyl)-1H-benziMidazol-2-yl]-1-piperidinyl]ethyl]-α,α-diMethylbenzeneacetic Acid;Benzeneacetic acid,4-[2-[4-[1-(2-ethoxyethyl)-1H-benziMidazol-2-yl]-1-piperidinyl]ethyl]-a,a-diMethyl-;BENZENEACETIC ACID, 4-(2-(4-(1-(2-ETHOXYETHYL)-1H-BENZIMIDAZOL-2-YL)-1-PIPERIDINYL)ETHYL-ALPHA, ALPHA-DIMETHYL-;2-[4-[2-[4-[1-(2-ethoxyethyl)benzoimidazol-2-yl]-1-piperidyl]ethyl]phenyl]-2-methyl-propanoic acid;4-[2-[4-[1-(2-Ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidinyl]ethyl]-alpha,alpha-dimethylbenzeneacetic acid;Bilasten;2-[4-[2-[4-[1-(2-ethoxyethyl)benzimidazol-2-yl]piperidin-1-yl]ethyl]phenyl]-2-methylpropanoic acid;the impurity of Bilastine
34 prices
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  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TCI Chemical
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number3489AH
  • Product descriptionBilastine
  • Packaging100mg
  • Price$270
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA325945
  • Product description2-(4-(2-(4-(1-(2-Ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoicacid 98+%
  • Packaging1g
  • Price$138
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA325945
  • Product description2-(4-(2-(4-(1-(2-Ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoicacid 98+%
  • Packaging250mg
  • Price$56
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA325945
  • Product description2-(4-(2-(4-(1-(2-Ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoicacid 98+%
  • Packaging100mg
  • Price$36
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA325945
  • Product description2-(4-(2-(4-(1-(2-Ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoicacid 98+%
  • Packaging50mg
  • Price$22
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA325945
  • Product description2-(4-(2-(4-(1-(2-Ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoicacid 98+%
  • Packaging10mg
  • Price$13
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA325945
  • Product description2-(4-(2-(4-(1-(2-Ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoicacid 98+%
  • Packaging5mg
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA325945
  • Product description2-(4-(2-(4-(1-(2-Ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoicacid 98+%
  • Packaging1mg
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0028346
  • Product descriptionBILASTINE 95.00%
  • Packaging1MG
  • Price$405.3
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0028346
  • Product descriptionBILASTINE 95.00%
  • Packaging10MG
  • Price$2310
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3524
  • Product descriptionBilastine
  • Packaging100mg
  • Price$1213
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3524
  • Product descriptionBilastine
  • Packaging50mg
  • Price$693
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3524
  • Product descriptionBilastine
  • Packaging10mg
  • Price$173
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS520639
  • Product descriptionBilastine ≥98%
  • Packaging1mg
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS520639
  • Product descriptionBilastine ≥98%
  • Packaging5mg
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS520639
  • Product descriptionBilastine ≥98%
  • Packaging10mg
  • Price$13
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3489AH Bilastine 100mg $270 2021-12-16 Buy
Ambeed A325945 2-(4-(2-(4-(1-(2-Ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoicacid 98+% 1g $138 2021-12-16 Buy
Ambeed A325945 2-(4-(2-(4-(1-(2-Ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoicacid 98+% 250mg $56 2021-12-16 Buy
Ambeed A325945 2-(4-(2-(4-(1-(2-Ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoicacid 98+% 100mg $36 2021-12-16 Buy
Ambeed A325945 2-(4-(2-(4-(1-(2-Ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoicacid 98+% 50mg $22 2021-12-16 Buy
Ambeed A325945 2-(4-(2-(4-(1-(2-Ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoicacid 98+% 10mg $13 2021-12-16 Buy
Ambeed A325945 2-(4-(2-(4-(1-(2-Ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoicacid 98+% 5mg $10 2021-12-16 Buy
Ambeed A325945 2-(4-(2-(4-(1-(2-Ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoicacid 98+% 1mg $6 2021-12-16 Buy
American Custom Chemicals Corporation API0028346 BILASTINE 95.00% 1MG $405.3 2021-12-16 Buy
American Custom Chemicals Corporation API0028346 BILASTINE 95.00% 10MG $2310 2021-12-16 Buy
ApexBio Technology B3524 Bilastine 100mg $1213 2021-12-16 Buy
ApexBio Technology B3524 Bilastine 50mg $693 2021-12-16 Buy
ApexBio Technology B3524 Bilastine 10mg $173 2021-12-16 Buy
Arctom AS520639 Bilastine ≥98% 1mg $6 2021-12-16 Buy
Arctom AS520639 Bilastine ≥98% 5mg $10 2021-12-16 Buy
Arctom AS520639 Bilastine ≥98% 10mg $13 2021-12-16 Buy

Properties

Melting point :202 °C
Boiling point :639.1±55.0 °C(Predicted)
Density :1.16±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
Water Solubility :Insoluble in water
solubility :DMSO:49.3(Max Conc. mg/mL);106.34(Max Conc. mM)
pka :4.40±0.10(Predicted)
form :powder to crystal
color :White to Light yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Bilastine, a potent and selective histamine H1 receptor antagonist, was approved in Europe in 2010 for the treatment of allergic rhinoconjunctivitis (AR) and urticaria (hives or skin rash). The original synthesis of bilastine involves alkylation of 2-piperidinyl-1H-benzimidazole with a phenethyltosylate, the para position of which is substituted with a dimethyloxazoline moiety serving as a masked carboxylic acid group. Alkylation of the benzimidazole nitrogen with 2-chloroethyl ethyl ether followed by unmasking of the oxazoline moiety with sulfuric acid provided bilastine.
In two major clinical trials, bilastine was effective at relieving allergic rhinitis as assessed by measuring the severity of nasal (obstruction, rhinorrhea, itching, sneezing) and nonnasal (ocular itching, tearing, ocular redness, itching of ears, and/or palate) symptoms.