BLU-285
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- $32 - $2400
- Product name: BLU-285
- CAS: 1703793-34-3
- MF: C26H27FN10
- MW: 498.56
- EINECS:-0
- MDL Number:MFCD31544325
- Synonyms:BLU-285;CPD1212;(1S)-1-(4-Fluorophenyl)-1-(2-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl}-5-pyrimidinyl)ethanamine;Avapritinib(BLU-285);BLU-285 (Avapritinib);BLU-285;BLU 285;BLU285;CS-2474;BLU-N
19 prices
Selected condition：
Brand
- Apolloscientific
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerApolloscientific
- Product numberBISN0062
- Product descriptionBLU-285 99%
- Packaging5mg
- Price$319
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0062
- Product descriptionBLU-285 99%
- Packaging10mg
- Price$479
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0062
- Product descriptionBLU-285 99%
- Packaging25mg
- Price$841
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number22985
- Product descriptionBLU-285 ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22985
- Product descriptionBLU-285 ≥98%
- Packaging5mg
- Price$161
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22985
- Product descriptionBLU-285 ≥98%
- Packaging10mg
- Price$283
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22985
- Product descriptionBLU-285 ≥98%
- Packaging25mg
- Price$618
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-7577
- Product descriptionAvapritinib 99.94%
- Packaging1mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-7577
- Product descriptionAvapritinib 99.94%
- Packaging5mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-7577
- Product descriptionAvapritinib 99.94%
- Packaging10mg
- Price$390
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-7577
- Product descriptionAvapritinib 99.94%
- Packaging25mg
- Price$690
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-7577
- Product descriptionAvapritinib 99.94%
- Packaging50mg
- Price$990
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-7577
- Product descriptionAvapritinib 99.94%
- Packaging100mg
- Price$1500
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD38000020
- Product descriptionBLU-285 98%
- Packaging5mg
- Price$117
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD38000020
- Product descriptionBLU-285 98%
- Packaging10mg
- Price$227
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD38000020
- Product descriptionBLU-285 98%
- Packaging25mg
- Price$503
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Apolloscientific | BISN0062 | BLU-285 99% | 5mg | $319 | 2021-12-16 | Buy |
| Apolloscientific | BISN0062 | BLU-285 99% | 10mg | $479 | 2021-12-16 | Buy |
| Apolloscientific | BISN0062 | BLU-285 99% | 25mg | $841 | 2021-12-16 | Buy |
| Cayman Chemical | 22985 | BLU-285 ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 22985 | BLU-285 ≥98% | 5mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 22985 | BLU-285 ≥98% | 10mg | $283 | 2024-03-01 | Buy |
| Cayman Chemical | 22985 | BLU-285 ≥98% | 25mg | $618 | 2024-03-01 | Buy |
| ChemScene | CS-7577 | Avapritinib 99.94% | 1mg | $80 | 2021-12-16 | Buy |
| ChemScene | CS-7577 | Avapritinib 99.94% | 5mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-7577 | Avapritinib 99.94% | 10mg | $390 | 2021-12-16 | Buy |
| ChemScene | CS-7577 | Avapritinib 99.94% | 25mg | $690 | 2021-12-16 | Buy |
| ChemScene | CS-7577 | Avapritinib 99.94% | 50mg | $990 | 2021-12-16 | Buy |
| ChemScene | CS-7577 | Avapritinib 99.94% | 100mg | $1500 | 2021-12-16 | Buy |
| Crysdot | CD38000020 | BLU-285 98% | 5mg | $117 | 2021-12-16 | Buy |
| Crysdot | CD38000020 | BLU-285 98% | 10mg | $227 | 2021-12-16 | Buy |
| Crysdot | CD38000020 | BLU-285 98% | 25mg | $503 | 2021-12-16 | Buy |
Properties
Density :1.42±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:83.11(Max Conc. mg/mL);166.7(Max Conc. mM)
form :A crystalline solid
pka :6.96±0.10(Predicted)
color :White to light yellow
InChIKey :DWYRIWUZIJHQKQ-JKXWNSIXNA-N
SMILES :C1N(C2N=CC([C@@](N)(C3C=CC(F)=CC=3)C)=CN=2)CCN(C2C3=CC(C4C=NN(C)C=4)=CN3N=CN=2)C1 |&1:6,r|
CAS DataBase Reference :1703793-34-3
storage temp. :Store at -20°C
solubility :DMSO:83.11(Max Conc. mg/mL);166.7(Max Conc. mM)
form :A crystalline solid
pka :6.96±0.10(Predicted)
color :White to light yellow
InChIKey :DWYRIWUZIJHQKQ-JKXWNSIXNA-N
SMILES :C1N(C2N=CC([C@@](N)(C3C=CC(F)=CC=3)C)=CN=2)CCN(C2C3=CC(C4C=NN(C)C=4)=CN3N=CN=2)C1 |&1:6,r|
CAS DataBase Reference :1703793-34-3
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Description
BLU-285 is a dual inhibitor of KIT receptor and platelet-derived growth factor receptor α (PDGFRα) tyrosine kinases with activating loop mutations (IC50s = 0.27 and 0.24 nM for KITD816V and PDGFRαD842V, respectively). It is >150-fold selective for KITD816V and PDGFRαD842V over a kinase panel at a concentration of 3 μM. BLU-285 also has activity against a panel of KIT and PDGFRα loop mutants identified in patients with gastrointestinal stromal tumors (GISTs; IC50s = <100 nM). It inhibits growth of cancer cell lines containing wild-type and mutant KIT and PDGFRα, demonstrating increased potency in cell lines expressing KIT and PDGFRα with activating loop mutations. BLU-285 (0.3-30 mg/kg) reduces tumor volume in a P815 KITD814Y mastocytoma allograft mouse model and a GIST patient-derived mouse xenograft model in a dose-dependent manner. Formulations containing BLU-285 have been used to treat KIT- and PDGFRα-driven malignancies.More related product prices
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