BAY 41-2272
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- $82 - $1700
- Product name: BAY 41-2272
- CAS: 256376-24-6
- MF: C20H17FN6
- MW: 360.39
- EINECS:
- MDL Number:MFCD06411391
- Synonyms:5-Cyclopropyl-2-[1-[(2-fluorophenyl)Methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyriMidinaMine;5-Cyclopropyl-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-amine;BAY 41-2272; 256376-24-6; UNII-34A162J6WB; IN1523; BAY-41-2272; 3-(4-AMINO-5-CYCLOPROPYLPYRIMIDIN-2-YL)-1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3;4-B]PYRIDINE;IN1523;UNII-34A162J6WB;3-(4-Amino-5-cyclopropylpyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo[3;4-Pyrimidinamine, 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-;Inhibitor,inhibit,Guanylate Cyclase,BAY 41 2272,BAY 412272,BAY 41-2272
27 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- ChemScene
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 1g
- ManufacturerAK Scientific
- Product number3081CR
- Product descriptionBay41-2272
- Packaging1mg
- Price$109
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA749144
- Product descriptionBAY41-2272 98+%
- Packaging5mg
- Price$82
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA749144
- Product descriptionBAY41-2272 98+%
- Packaging10mg
- Price$138
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA749144
- Product descriptionBAY41-2272 98+%
- Packaging25mg
- Price$233
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA749144
- Product descriptionBAY41-2272 98+%
- Packaging50mg
- Price$303
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0008609
- Product descriptionBAY 41-2272 95.00%
- Packaging25MG
- Price$1205.47
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7664
- Product descriptionBAY41-2272
- Packaging5mg
- Price$135
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7664
- Product descriptionBAY41-2272
- Packaging10mg
- Price$239
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7664
- Product descriptionBAY41-2272
- Packaging25mg
- Price$473
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7664
- Product descriptionBAY41-2272
- Packaging50mg
- Price$859
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7664
- Product descriptionBAY41-2272
- Packaging100mg
- Price$1244
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number10057
- Product descriptionBAY 41-2272 ≥95%
- Packaging5mg
- Price$106
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10057
- Product descriptionBAY 41-2272 ≥95%
- Packaging10mg
- Price$198
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10057
- Product descriptionBAY 41-2272 ≥95%
- Packaging25mg
- Price$414
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10057
- Product descriptionBAY 41-2272 ≥95%
- Packaging50mg
- Price$775
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-5390
- Product descriptionBAY41-2272 99.97%
- Packaging5mg
- Price$96
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3081CR | Bay41-2272 | 1mg | $109 | 2021-12-16 | Buy |
| Ambeed | A749144 | BAY41-2272 98+% | 5mg | $82 | 2021-12-16 | Buy |
| Ambeed | A749144 | BAY41-2272 98+% | 10mg | $138 | 2021-12-16 | Buy |
| Ambeed | A749144 | BAY41-2272 98+% | 25mg | $233 | 2021-12-16 | Buy |
| Ambeed | A749144 | BAY41-2272 98+% | 50mg | $303 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008609 | BAY 41-2272 95.00% | 25MG | $1205.47 | 2021-12-16 | Buy |
| ApexBio Technology | B7664 | BAY41-2272 | 5mg | $135 | 2021-12-16 | Buy |
| ApexBio Technology | B7664 | BAY41-2272 | 10mg | $239 | 2021-12-16 | Buy |
| ApexBio Technology | B7664 | BAY41-2272 | 25mg | $473 | 2021-12-16 | Buy |
| ApexBio Technology | B7664 | BAY41-2272 | 50mg | $859 | 2021-12-16 | Buy |
| ApexBio Technology | B7664 | BAY41-2272 | 100mg | $1244 | 2021-12-16 | Buy |
| Cayman Chemical | 10057 | BAY 41-2272 ≥95% | 5mg | $106 | 2024-03-01 | Buy |
| Cayman Chemical | 10057 | BAY 41-2272 ≥95% | 10mg | $198 | 2024-03-01 | Buy |
| Cayman Chemical | 10057 | BAY 41-2272 ≥95% | 25mg | $414 | 2024-03-01 | Buy |
| Cayman Chemical | 10057 | BAY 41-2272 ≥95% | 50mg | $775 | 2024-03-01 | Buy |
| ChemScene | CS-5390 | BAY41-2272 99.97% | 5mg | $96 | 2021-12-16 | Buy |
Properties
Melting point :210.5-211.4 °C
Boiling point :496.1±45.0 °C(Predicted)
Density :1.49±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,2-8°C
solubility :DMSO: 26 mg/mL at 60 °C
form :solid
pka :2.71±0.10(Predicted)
color :white
Boiling point :496.1±45.0 °C(Predicted)
Density :1.49±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,2-8°C
solubility :DMSO: 26 mg/mL at 60 °C
form :solid
pka :2.71±0.10(Predicted)
color :white
Safety Information
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Description
Soluble guanylate cyclase (sGC), a receptor for nitric oxide (NO), is a heterodimer consisting of alpha and beta subunits, with the beta subunit featuring a heme-nitric oxide (H-NOX) binding domain. The binding of NO to H-NOX induces sGC to generate the second messenger cGMP. BAY 41-2272 is a pyrazolopyridine compound that acts as an activator of sGC, stimulating activity to a level that would be expected to cause biologically important increases in cGMP at concentrations as low as 10-100 nM. Through this effect, it inhibits platelet aggregation (IC50 = 36 nM), induces relaxation of phenylephrine-preconstricted rabbit aorta rings (IC50 = 304 nM), and reduces proliferation in smooth muscle. BAY 41-2272 is effective in vivo, as it decreases mean arterial blood pressure in hypertensive rats. Unlike another sGC activator, YC-1 , BAY 41-2772 does not inhibit phosphodiesterases.More related product prices
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