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ChemicalBook >> CAS DataBase List >> Atractylenolide-1

Atractylenolide-1

Atractylenolide-1 price.
  • $45 - $2839
  • Product name: Atractylenolide-1
  • CAS: 73069-13-3
  • MF: C15H18O2
  • MW: 230.3
  • EINECS:
  • MDL Number:MFCD09037395
  • Synonyms:ATRACTYLENOLIDE-1;3,8aβ-Dimethyl-5-methylene-2,4,4aα,5,6,7,8,8a-octahydronaphtho[2,3-b]furan-2-one;Eudesma-4(15),7(11),8-trien-12-olide;8,9-Dehydroasterolide;(4aS,8aS)-4a,5,6,7,8,8a-Hexahydro-3,8a-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one;Atractylenolide Ⅰ;Atractylenolide I, >99%;Naphtho[2,3-b]furan-2(4H)-one,4a,5,6,7,8,8a-hexahydro-3,8a-dimethyl-5-methylene-, (4aS,8aS)-
36 prices
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Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
Package
  • 5MG
  • 10mg
  • 20mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberX1093
  • Product descriptionAtractylenolide I
  • Packaging10mg
  • Price$171
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0006575
  • Product descriptionATRACTYLENOLIDE I 95.00%
  • Packaging5MG
  • Price$314.6
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberN2541
  • Product descriptionAtractylenolide I
  • Packaging20mg
  • Price$365
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN99944
  • Product descriptionAtractylenolide I ≥98%
  • Packaging20mg
  • Price$118
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number1414
  • Product descriptionAtractylenolide I
  • Packaging5mg
  • Price$49
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number1414
  • Product descriptionAtractylenolide I
  • Packaging10mg
  • Price$89
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number1414
  • Product descriptionAtractylenolide I
  • Packaging25mg
  • Price$169
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number1414
  • Product descriptionAtractylenolide I
  • Packaging100mg
  • Price$369
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number1414
  • Product descriptionAtractylenolide I
  • Packaging250mg
  • Price$779
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number1414
  • Product descriptionAtractylenolide I
  • Packaging1g
  • Price$2290
  • Updated2021-12-16
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  • ManufacturerBiorbyt Ltd
  • Product numberorb573063
  • Product descriptionAtractylenolide 1 >98%,Standard References Grade
  • Packaging100mg
  • Price$912.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb573063
  • Product descriptionAtractylenolide 1 >98%,Standard References Grade
  • Packaging250mg
  • Price$1654.1
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb573063
  • Product descriptionAtractylenolide 1 >98%,Standard References Grade
  • Packaging1g
  • Price$2839
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA73867
  • Product descriptionAtractylenolide I
  • Packaging5mg
  • Price$52
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA73867
  • Product descriptionAtractylenolide I
  • Packaging10mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA73867
  • Product descriptionAtractylenolide I
  • Packaging25mg
  • Price$180
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X1093 Atractylenolide I 10mg $171 2021-12-16 Buy
American Custom Chemicals Corporation API0006575 ATRACTYLENOLIDE I 95.00% 5MG $314.6 2021-12-16 Buy
ApexBio Technology N2541 Atractylenolide I 20mg $365 2021-12-16 Buy
Arctom CFN99944 Atractylenolide I ≥98% 20mg $118 2021-12-16 Buy
AvaChem 1414 Atractylenolide I 5mg $49 2021-12-16 Buy
AvaChem 1414 Atractylenolide I 10mg $89 2021-12-16 Buy
AvaChem 1414 Atractylenolide I 25mg $169 2021-12-16 Buy
AvaChem 1414 Atractylenolide I 100mg $369 2021-12-16 Buy
AvaChem 1414 Atractylenolide I 250mg $779 2021-12-16 Buy
AvaChem 1414 Atractylenolide I 1g $2290 2021-12-16 Buy
Biorbyt Ltd orb573063 Atractylenolide 1 >98%,Standard References Grade 100mg $912.9 2021-12-16 Buy
Biorbyt Ltd orb573063 Atractylenolide 1 >98%,Standard References Grade 250mg $1654.1 2021-12-16 Buy
Biorbyt Ltd orb573063 Atractylenolide 1 >98%,Standard References Grade 1g $2839 2021-12-16 Buy
Biosynth Carbosynth FA73867 Atractylenolide I 5mg $52 2021-12-16 Buy
Biosynth Carbosynth FA73867 Atractylenolide I 10mg $90 2021-12-16 Buy
Biosynth Carbosynth FA73867 Atractylenolide I 25mg $180 2021-12-16 Buy

Properties

Melting point :121-123 °C(Solv: ligroine (8032-32-4))
Boiling point :405.0±44.0 °C(Predicted)
Density :1.12
Flash point :170℃
storage temp. :2-8°C
solubility :methanol: soluble1mg/mL, clear, colorless
form :powder
color :White
InChIKey :ZTVSGQPHMUYCRS-SWLSCSKDSA-N

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
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Description

Atractylenolide I is a sesquiterpene that has been found in the rhizomes of A. macrocephala and has diverse biological activities, including anti-inflammatory, anti-angiogenic, anti-tumor, and antidepressant properties. It inhibits LPS-induced increases in TNF-α and nitric oxide (NO) production, as well as inducible nitric oxide synthase (iNOS) activity, in murine peritoneal macrophages (IC50s = 23.1, 41, and 67.3 μM, respectively). Atractylenolide I reduces pouch fluid weight, inflammatory cell count, granuloma weight, and vascular index (ID50s = 24.18, 19.46, 14.44, and 15.15 mg/kg, respectively) in a mouse air pouch granuloma model induced by Freund''s complete adjuvant (FCA). It also reduces the number of microvessels in the air pouch wall by 58.27% when administered at a dose of 20 mg/kg and reduces the blood levels of TNF-α, IL-1β, IL-6, VEGF, placenta growth factor (PlGF), and bFGF in a dose-dependent manner in a mouse model of FCA-induced granuloma. Atractylenolide I inhibits the growth of T-24, 5637, RT4, and 253J bladder cancer cells in vitro (IC50s = 12.8-63.7 μM) and reduces tumor growth in T-24 and 253J mouse xenograft models in a dose-dependent manner. In a mouse model of depression induced by chronic unpredictable mild stress, atractylenolide I reverses stress-induced decreases in hippocampal levels of serotonin (5-HT; ) and norepinephrine and reduces immobility time in the forced swim and tail suspension tests in a dose-dependent manner, indicating antidepressant-like activity.

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