APS-2-79
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- $33 - $1071
- Product name: APS-2-79
- CAS: 2002381-31-7
- MF: C23H22ClN3O3
- MW: 423.9
- EINECS:-0
- MDL Number:MFCD30536203
- Synonyms:APS-2-79;APS-2-79 (hydrochloride);APS 2 79;APS279;APS-279;CS-2444;APS-2-79 hydrochloride >=98% (HPLC);6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine hydrochloride;MAP2K,MAPKK,Inhibitor,Mitogen-activated protein kinase kinase,APS 2 79 hydrochloride,APS279 hydrochloride,inhibit,MEK
15 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Cayman Chemical
- DC Chemicals
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- ManufacturerAK Scientific
- Product number1076EH
- Product descriptionAPS-2-79hydrochloride
- Packaging5mg
- Price$197
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number1076EH
- Product descriptionAPS-2-79hydrochloride
- Packaging10mg
- Price$275
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004648
- Product descriptionAPS-2-79 HYDROCHLORIDE 95.00%
- Packaging5MG
- Price$496.9
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7820
- Product descriptionAPS-2-79
- Packaging100mg
- Price$1071
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7820
- Product descriptionAPS-2-79
- Packaging50mg
- Price$725
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7820
- Product descriptionAPS-2-79
- Packaging25mg
- Price$410
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7820
- Product descriptionAPS-2-79
- Packaging10mg
- Price$189
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7820
- Product descriptionAPS-2-79
- Packaging5mg
- Price$122
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2611
- Product descriptionAPS-2-79 98%
- Packaging25mg
- Price$330
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number22137
- Product descriptionAPS-2-79 (hydrochloride) ≥95%
- Packaging25mg
- Price$356
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22137
- Product descriptionAPS-2-79 (hydrochloride) ≥95%
- Packaging10mg
- Price$160
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22137
- Product descriptionAPS-2-79 (hydrochloride) ≥95%
- Packaging5mg
- Price$89
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22137
- Product descriptionAPS-2-79 (hydrochloride) ≥95%
- Packaging1mg
- Price$33
- Updated2024-03-01
- Buy
- ManufacturerDC Chemicals
- Product numberDC9808
- Product descriptionAPS-2-79hydrochloride >98%
- Packaging100mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC9808
- Product descriptionAPS-2-79hydrochloride >98%
- Packaging250mg
- Price$700
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 1076EH | APS-2-79hydrochloride | 5mg | $197 | 2021-12-16 | Buy |
| AK Scientific | 1076EH | APS-2-79hydrochloride | 10mg | $275 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004648 | APS-2-79 HYDROCHLORIDE 95.00% | 5MG | $496.9 | 2021-12-16 | Buy |
| ApexBio Technology | B7820 | APS-2-79 | 100mg | $1071 | 2021-12-16 | Buy |
| ApexBio Technology | B7820 | APS-2-79 | 50mg | $725 | 2021-12-16 | Buy |
| ApexBio Technology | B7820 | APS-2-79 | 25mg | $410 | 2021-12-16 | Buy |
| ApexBio Technology | B7820 | APS-2-79 | 10mg | $189 | 2021-12-16 | Buy |
| ApexBio Technology | B7820 | APS-2-79 | 5mg | $122 | 2021-12-16 | Buy |
| Axon Medchem | Axon2611 | APS-2-79 98% | 25mg | $330 | 2021-12-16 | Buy |
| Cayman Chemical | 22137 | APS-2-79 (hydrochloride) ≥95% | 25mg | $356 | 2024-03-01 | Buy |
| Cayman Chemical | 22137 | APS-2-79 (hydrochloride) ≥95% | 10mg | $160 | 2024-03-01 | Buy |
| Cayman Chemical | 22137 | APS-2-79 (hydrochloride) ≥95% | 5mg | $89 | 2024-03-01 | Buy |
| Cayman Chemical | 22137 | APS-2-79 (hydrochloride) ≥95% | 1mg | $33 | 2024-03-01 | Buy |
| DC Chemicals | DC9808 | APS-2-79hydrochloride >98% | 100mg | $400 | 2021-12-16 | Buy |
| DC Chemicals | DC9808 | APS-2-79hydrochloride >98% | 250mg | $700 | 2021-12-16 | Buy |
Properties
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :A crystalline solid
solubility :Soluble in DMSO
form :A crystalline solid
Safety Information
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Description
APS-2-79 is an inhibitor of MAPK signaling dependent on kinase suppressor of Ras (KSR). It inhibits ATPbiotin binding to KSR2 in KSR2-MEK1 complexes (IC50 = 120 nM), stabilizes KSR2 in an inactive state, and reduces interactions between B-RAF and KSR2-MEK1 complexes. APS-2-79 (5 μM) inhibits KSR-stimulated phosphorylation of MEK and ERK in HEK293H cells. It enhances the efficacy of the MEK inhibitor trametinib , further reducing cell viability in HCT116 and A549 cell lines containing K-Ras mutations, but not B-RAF mutant SK-MEL-239 and A375 cell lines, when used at a concentration of 1 μM.Related product price
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