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ChemicalBook >> CAS DataBase List >> BIX 01294, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride

BIX 01294, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride

BIX 01294, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride price.
  • $33 - $2395.3
  • Product name: BIX 01294, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride
  • CAS: 935693-62-2
  • MF: C28H38N6O2
  • MW: 490.64
  • EINECS:
  • MDL Number:MFCD11045283
  • Synonyms:2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinaminetrihydrochloride;BIX 01294;BIX 01294 hydrate trihydrochloride;BIX 01294, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride;4-QuinazolinaMine, 2-(hexahydro-4-Methyl-1H-1,4-diazepin-1-yl)-6,7-diMethoxy-N-[1-(phenylMethyl)-4-piperidinyl]-;2-(Hexahydro-4-Methyl-1H-1,4-diazepin-1-yl)-6,7-diMethoxy-N-[1-(phenylMethyl)-4-piperidinyl]-4-quinazolinaMine hydrate trihydrochloride;BIX 01294 (free base);2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine
26 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Axon Medchem
  • Biorbyt Ltd
  • Chemenu
  • ChemScene
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 100mg
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  • 1g
  • 10
  • 1000mg
  • 10mM(in 1mL DMSO)
  • 1mg
  • 5mg
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  • 25mg
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  • 250mg
  • 5g
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-0051-M025
  • Product descriptionBIX01294 ≥98%(NMR,HPLC)
  • Packaging25mg
  • Price$240
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number1328AH
  • Product description2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinaminehydratetrihydrochloride
  • Packaging5g
  • Price$1072
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN5475
  • Product descriptionBIX-01294
  • Packaging10mg
  • Price$217
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA337768
  • Product descriptionBIX-01294 98+%
  • Packaging1mg
  • Price$33
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA337768
  • Product descriptionBIX-01294 98+%
  • Packaging5mg
  • Price$67
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA337768
  • Product descriptionBIX-01294 98+%
  • Packaging10mg
  • Price$113
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA337768
  • Product descriptionBIX-01294 98+%
  • Packaging50mg
  • Price$378
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA337768
  • Product descriptionBIX-01294 98+%
  • Packaging250mg
  • Price$935
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1909
  • Product descriptionBIX01294
  • Packaging5mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1909
  • Product descriptionBIX01294
  • Packaging10mM(in 1mL DMSO)
  • Price$136
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1909
  • Product descriptionBIX01294
  • Packaging25mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1692
  • Product descriptionBIX01294trihydrochloride 99%
  • Packaging2x50mg
  • Price$396
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181211
  • Product descriptionBIX01294 >98%
  • Packaging100mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181211
  • Product descriptionBIX01294 >98%
  • Packaging250mg
  • Price$1208.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181211
  • Product descriptionBIX01294 >98%
  • Packaging1000mg
  • Price$2395.3
  • Updated2021-12-16
  • Buy
  • ManufacturerChemenu
  • Product numberCM142735
  • Product descriptionN-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine 98%
  • Packaging10mg
  • Price$121
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-0051-M025 BIX01294 ≥98%(NMR,HPLC) 25mg $240 2021-12-16 Buy
AK Scientific 1328AH 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinaminehydratetrihydrochloride 5g $1072 2021-12-16 Buy
AK Scientific SYN5475 BIX-01294 10mg $217 2021-12-16 Buy
Ambeed A337768 BIX-01294 98+% 1mg $33 2021-12-16 Buy
Ambeed A337768 BIX-01294 98+% 5mg $67 2021-12-16 Buy
Ambeed A337768 BIX-01294 98+% 10mg $113 2021-12-16 Buy
Ambeed A337768 BIX-01294 98+% 50mg $378 2021-12-16 Buy
Ambeed A337768 BIX-01294 98+% 250mg $935 2021-12-16 Buy
ApexBio Technology A1909 BIX01294 5mg $50 2021-12-16 Buy
ApexBio Technology A1909 BIX01294 10mM(in 1mL DMSO) $136 2021-12-16 Buy
ApexBio Technology A1909 BIX01294 25mg $200 2021-12-16 Buy
Axon Medchem Axon1692 BIX01294trihydrochloride 99% 2x50mg $396 2021-12-16 Buy
Biorbyt Ltd orb181211 BIX01294 >98% 100mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb181211 BIX01294 >98% 250mg $1208.7 2021-12-16 Buy
Biorbyt Ltd orb181211 BIX01294 >98% 1000mg $2395.3 2021-12-16 Buy
Chemenu CM142735 N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine 98% 10mg $121 2021-12-16 Buy

Properties

Boiling point :654.6±65.0 °C(Predicted)
Density :1.195±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 50 mg/ml), or in Water (up to 50 mg/ml).
pka :9.34±0.70(Predicted)
form :Off-white solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
InChIKey :BZOWJAYUMMHCDW-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

Histone Lysine Methyltransferase Inhibitor (BIX-01294) is a G9a (histone lysine methyltransferase (HMTase)) inhibitor, specifically shown to inhibit the G9a-mediated generation of H3K9me2 (histone H3 lysine 9 dimethylation), not competitive with the S-adenosyl-methionine cofactor. Levels of H3K9me2 are restored with removal of BIX-01294. This molecule allows transient modulation of HMTase behavior, providing a tool for studying consequent effects on gene expression and chromatin organization. Histone Lysine Methyltransferase Inhibitor is an inhibitor of EHMT.