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ChemicalBook >> CAS DataBase List >> (+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST

(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST

(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST price.
6 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
  • Medical Isotopes, Inc.
  • TRC
Package
  • 50mg
  • 100mg
  • 250mg
  • ManufacturerAK Scientific
  • Product number0120BA
  • Product descriptionDL-2-Amino-3-phosphonopropionic acid
  • Packaging50mg
  • Price$139
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13852
  • Product descriptionDL-AP3 ≥95%
  • Packaging100mg
  • Price$68
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13852
  • Product descriptionDL-AP3 ≥95%
  • Packaging50mg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number38685
  • Product descriptionDL-2-Amino-3-phosphonopropionic acid
  • Packaging250mg
  • Price$650
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberA627553
  • Product descriptionDL-2-Amino-3-phosphonopropionicAcid(AP3)
  • Packaging100mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberA627553
  • Product descriptionDL-2-Amino-3-phosphonopropionicAcid(AP3)
  • Packaging250mg
  • Price$160
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 0120BA DL-2-Amino-3-phosphonopropionic acid 50mg $139 2021-12-16 Buy
Cayman Chemical 13852 DL-AP3 ≥95% 100mg $68 2024-03-01 Buy
Cayman Chemical 13852 DL-AP3 ≥95% 50mg $37 2024-03-01 Buy
Medical Isotopes, Inc. 38685 DL-2-Amino-3-phosphonopropionic acid 250mg $650 2021-12-16 Buy
TRC A627553 DL-2-Amino-3-phosphonopropionicAcid(AP3) 100mg $75 2021-12-16 Buy
TRC A627553 DL-2-Amino-3-phosphonopropionicAcid(AP3) 250mg $160 2021-12-16 Buy

Properties

Boiling point :481.6±55.0 °C(Predicted)
Density :1.763±0.06 g/cm3(Predicted)
solubility :PBS (pH 7.2): 2 mg/ml
form :White powder.
pka :1.22±0.10(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Metabotropic glutamate receptors (mGluR1-8) are G protein-coupled receptors that function to modulate brain excitatory signaling via presynaptic, postsynaptic, and glial mechanisms. DL-AP3 is a competitive mGluR1 antagonist that demonstrates a Ki value of 298 μM and an IC50 value of 1mM for rat mGluR1α when challenged with glutamate. DL-AP3 can antagonize excitatory amino acid-induced phosphoinositide hydrolysis, induce Ca2+ mobilization in rat hippocampal slices, and inhibit phosphoserine phosphatase in rat brain cortex. At concentrations from 10-300 μM DL-AP3 has been used to characterize the role of mGluR in long-term potentiation in the hippocampus in a model of learning and memory, the release of glutamate in Parkinson’s disease, and the increased activity of mGluR implicated in fragile X syndrome.

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