Benzenepropanoic acid, 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)Methoxy]-
![Benzenepropanoic acid, 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)Methoxy]- price.](/CAS/GIF/530141-72-1.gif)
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- $40 - $1100
- Product name: Benzenepropanoic acid, 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)Methoxy]-
- CAS: 530141-72-1
- MF: C29H27NO8
- MW: 517.53
- EINECS:-0
- MDL Number:MFCD08272618
- Synonyms:Benzenepropanoic acid, 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)Methoxy]-;T-5224;3-(5-(4-(Cyclopentyloxy)-2-hydroxybenzoyl)-2-((3-oxo-2,3-dihydrobenzo[d]isoxazol-6-yl)methoxy);3-(5-(4-(Cyclopentyloxy)-2-hydroxybenzoyl)-2-((3-hydroxybenzo-[d]isoxazol-6-yl)methoxy)phenyl);T-5225;3-[5-[4-(cyclopentoxy)-2-hydroxy-benzoyl]-2-[(3-hydroxy-1,2-benzo xazol-6-yl)methoxy]phenyl]propanoic acid;CS-1217;T-5224; T5224; T 5224.
21 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 1mg
- 5MG
- 10mg
- 25mg
- 10mM(in 1mL DMSO)
- 50mg
- 100mg
- 250mg
- ManufacturerAK Scientific
- Product number0423DB
- Product description3-[5-(4-Cyclopentyloxy-2-hydroxybenzoyl)-2-[(3-oxo-1,2-benzoxazol-6-yl)methoxy]phenyl]propanoicacid
- Packaging10mg
- Price$430
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0378209
- Product description3-(5-([4-(CYCLOPENTYLOXY)-2-HYDROXYPHENYL]CARBONYL)-2-[(3-HYDROXY-1,2-BENZOXAZOL-6-YL)METHOXY]PHENYL)PROPANOIC ACID 95.00%
- Packaging5MG
- Price$500.95
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4664
- Product descriptionT-5224
- Packaging5mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4664
- Product descriptionT-5224
- Packaging10mM(in 1mL DMSO)
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4664
- Product descriptionT-5224
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4664
- Product descriptionT-5224
- Packaging50mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4664
- Product descriptionT-5224
- Packaging100mg
- Price$750
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number22904
- Product descriptionT-5224 ≥98%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22904
- Product descriptionT-5224 ≥98%
- Packaging5mg
- Price$161
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22904
- Product descriptionT-5224 ≥98%
- Packaging10mg
- Price$299
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22904
- Product descriptionT-5224 ≥98%
- Packaging25mg
- Price$638
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-3190
- Product descriptionT-5224 99.59%
- Packaging5mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3190
- Product descriptionT-5224 99.59%
- Packaging10mg
- Price$180
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3190
- Product descriptionT-5224 99.59%
- Packaging50mg
- Price$540
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3190
- Product descriptionT-5224 99.59%
- Packaging100mg
- Price$888
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31001612
- Product descriptionT-5224 98+%
- Packaging25mg
- Price$270
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 0423DB | 3-[5-(4-Cyclopentyloxy-2-hydroxybenzoyl)-2-[(3-oxo-1,2-benzoxazol-6-yl)methoxy]phenyl]propanoicacid | 10mg | $430 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0378209 | 3-(5-([4-(CYCLOPENTYLOXY)-2-HYDROXYPHENYL]CARBONYL)-2-[(3-HYDROXY-1,2-BENZOXAZOL-6-YL)METHOXY]PHENYL)PROPANOIC ACID 95.00% | 5MG | $500.95 | 2021-12-16 | Buy |
| ApexBio Technology | B4664 | T-5224 | 5mg | $100 | 2021-12-16 | Buy |
| ApexBio Technology | B4664 | T-5224 | 10mM(in 1mL DMSO) | $110 | 2021-12-16 | Buy |
| ApexBio Technology | B4664 | T-5224 | 10mg | $150 | 2021-12-16 | Buy |
| ApexBio Technology | B4664 | T-5224 | 50mg | $450 | 2021-12-16 | Buy |
| ApexBio Technology | B4664 | T-5224 | 100mg | $750 | 2021-12-16 | Buy |
| Cayman Chemical | 22904 | T-5224 ≥98% | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 22904 | T-5224 ≥98% | 5mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 22904 | T-5224 ≥98% | 10mg | $299 | 2024-03-01 | Buy |
| Cayman Chemical | 22904 | T-5224 ≥98% | 25mg | $638 | 2024-03-01 | Buy |
| ChemScene | CS-3190 | T-5224 99.59% | 5mg | $120 | 2021-12-16 | Buy |
| ChemScene | CS-3190 | T-5224 99.59% | 10mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-3190 | T-5224 99.59% | 50mg | $540 | 2021-12-16 | Buy |
| ChemScene | CS-3190 | T-5224 99.59% | 100mg | $888 | 2021-12-16 | Buy |
| Crysdot | CD31001612 | T-5224 98+% | 25mg | $270 | 2021-12-16 | Buy |
Properties
Density :1.376±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:30.5(Max Conc. mg/mL);58.93(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.64(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);57.97(Max Conc. mM) form :A crystalline solid
pka :4.61±0.10(Predicted)
color :White to yellow
storage temp. :Store at -20°C
solubility :DMSO:30.5(Max Conc. mg/mL);58.93(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.64(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);57.97(Max Conc. mM) form :A crystalline solid
pka :4.61±0.10(Predicted)
color :White to yellow
Safety Information
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Description
T-5224 is an inhibitor of c-fos/activator protein 1 (AP-1). It inhibits the DNA binding activity of c-fos/AP-1 without affecting the activity of C/EBPα, ATF2, MyoD, Sp1, and NF-κB/p65 in vitro. It shows inhibitory activity in a c-fos/AP-1 promoter luciferase assay without changing c-fos family protein expression levels in TNF-α-stimulated NIH/3T3 cells. Administration of T-5224 (30 mg/kg) inhibits the development of collagen-induced arthritis in mice through reduction of IL-1β production, neutrophil infiltration, and synovial cell proliferation. It reduces the inflammatory cytokine response in LPS-challenged mice, lowering levels of TNF-α and HMGB1 in the serum and MIP-1α and MCP-1 in the liver. T-5224 reduces in vivo necrosis of liver tissue and improves survival rates in LPS-challenged mice. T-5224 also exhibits anticancer activity, reducing proliferation and migration of HSC-3-M3 head and neck squamous carcinoma cells in vitro and the number of metastases in an HSC-3-M3 orthotopic xenograft model in vivo.Related product price
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