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ChemicalBook >> CAS DataBase List >> [4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID

[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID

[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID price.
  • $36 - $800
  • Product name: [4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID
  • CAS: 475085-57-5
  • MF: C25H29N3O3
  • MW: 419.52
  • EINECS:
  • MDL Number:MFCD11976884
  • Synonyms:[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID;ACT 333679;2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid;Selexipag Active Metabolite (ACT-333679);{4-[(5,6-Diphenyl-2-pyrazinyl)(isopropyl)amino]butoxy}acetic acid;MRE-269 (ACT-333679);MRE-269 Selexipag Active Metabolite;MRE-269 S
17 prices
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Brand
  • AK Scientific
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
  • Usbiological
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • ManufacturerAK Scientific
  • Product numberY0263
  • Product description(4-((5,6-Diphenylpyrazinyl)(1-methylethyl)amino)butoxy)-aceticacid
  • Packaging5mg
  • Price$194
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number10010412
  • Product descriptionMRE-269 ≥98%
  • Packaging1mg
  • Price$36
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10010412
  • Product descriptionMRE-269 ≥98%
  • Packaging5mg
  • Price$87
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10010412
  • Product descriptionMRE-269 ≥98%
  • Packaging10mg
  • Price$155
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10010412
  • Product descriptionMRE-269 ≥98%
  • Packaging50mg
  • Price$510
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM168933
  • Product description2-(4-((5,6-diphenylpyrazin-2-yl)(isopropyl)amino)butoxy)aceticacid 95%+
  • Packaging50mg
  • Price$720
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6104
  • Product descriptionMRE-269 99.46%
  • Packaging5mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6104
  • Product descriptionMRE-269 99.46%
  • Packaging10mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6104
  • Product descriptionMRE-269 99.46%
  • Packaging50mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6104
  • Product descriptionMRE-269 99.46%
  • Packaging100mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11120260
  • Product descriptionMRE-269 95+%
  • Packaging25mg
  • Price$170
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11120260
  • Product descriptionMRE-269 95+%
  • Packaging50mg
  • Price$210
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11120260
  • Product descriptionMRE-269 95+%
  • Packaging100mg
  • Price$385
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10437
  • Product descriptionMRE-269 >98%
  • Packaging100mg
  • Price$500
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10437
  • Product descriptionMRE-269 >98%
  • Packaging250mg
  • Price$800
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberM750110
  • Product descriptionMRE-269
  • Packaging10mg
  • Price$120
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific Y0263 (4-((5,6-Diphenylpyrazinyl)(1-methylethyl)amino)butoxy)-aceticacid 5mg $194 2021-12-16 Buy
Cayman Chemical 10010412 MRE-269 ≥98% 1mg $36 2024-03-01 Buy
Cayman Chemical 10010412 MRE-269 ≥98% 5mg $87 2024-03-01 Buy
Cayman Chemical 10010412 MRE-269 ≥98% 10mg $155 2024-03-01 Buy
Cayman Chemical 10010412 MRE-269 ≥98% 50mg $510 2024-03-01 Buy
Chemenu CM168933 2-(4-((5,6-diphenylpyrazin-2-yl)(isopropyl)amino)butoxy)aceticacid 95%+ 50mg $720 2021-12-16 Buy
ChemScene CS-6104 MRE-269 99.46% 5mg $60 2021-12-16 Buy
ChemScene CS-6104 MRE-269 99.46% 10mg $110 2021-12-16 Buy
ChemScene CS-6104 MRE-269 99.46% 50mg $250 2021-12-16 Buy
ChemScene CS-6104 MRE-269 99.46% 100mg $450 2021-12-16 Buy
Crysdot CD11120260 MRE-269 95+% 25mg $170 2021-12-16 Buy
Crysdot CD11120260 MRE-269 95+% 50mg $210 2021-12-16 Buy
Crysdot CD11120260 MRE-269 95+% 100mg $385 2021-12-16 Buy
DC Chemicals DC10437 MRE-269 >98% 100mg $500 2021-12-16 Buy
DC Chemicals DC10437 MRE-269 >98% 250mg $800 2021-12-16 Buy
TRC M750110 MRE-269 10mg $120 2021-12-16 Buy

Properties

Melting point :116 - 118°C
Boiling point :602.1±55.0 °C(Predicted)
Density :1.160
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka :3.51±0.10(Predicted)
form :Solid
color :Off-White to Light Yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Prostacyclin (PGI2) is a potent vasorelaxant and inhibitor of platelet aggregation. It mediates its actions by binding to a specific G protein-coupled receptor, the IP receptor, on the surface of endothelial cells, arterial smooth muscle, and platelets. The IP receptor also participates in signal transduction of the pain response, cardioprotection, and inflammation. MRE-269 is the active form of the prodrug NS-304. It is a potent and selective agonist for the human IP receptor with a Ki value of 20 nM. In contrast to PGI2, which has a half-life of 30 seconds to a few minutes in vivo, plasma concentrations of MRE-269 remain near peak levels for more than eight hours in rats and dogs. Unlike the PGI2 analogues, beraprost and iloprost, MRE-269 lacks high affinity for the EP3 receptor. As a result, MRE-269 induces vasodilation equally in large and small pulmonary arteries, whereas vasodilation of small arteries by beraprost and iloprost is reduced via EP3-mediated vasoconstriction.

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