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ChemicalBook >> CAS DataBase List >> (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide

(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide

(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide price.
  • $104 - $1390
  • Product name: (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide
  • CAS: 432531-71-0
  • MF: C18H15N5O6S2
  • MW: 461.47
  • EINECS:
  • MDL Number:
  • Synonyms:(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide;Necrosulfonami;N-[4-[[(3-Methoxypyrazinyl)aMino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenaMide;(E)-N-[4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophen-2-yl)prop-2-enamide;MLKL Inhibitor, Necrosulfonamide - CAS 432531-71-0 - Calbiochem;Necrosulfonamide(b);2-Propenamide, N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-;(E/Z)-Necrosulfonamide
10 prices
Selected condition：
Brand
  • aablocks
  • CSNpharm
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • Manufactureraablocks
  • Product numberAA00DEZZ
  • Product description(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide 98+%
  • Packaging5mg
  • Price$104
  • Updated2021-12-16
  • Buy
  • Manufactureraablocks
  • Product numberAA00DEZZ
  • Product description(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide 98+%
  • Packaging10mg
  • Price$147
  • Updated2021-12-16
  • Buy
  • Manufactureraablocks
  • Product numberAA00DEZZ
  • Product description(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide 98+%
  • Packaging25mg
  • Price$222
  • Updated2021-12-16
  • Buy
  • Manufactureraablocks
  • Product numberAA00DEZZ
  • Product description(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide 98+%
  • Packaging50mg
  • Price$348
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN24728
  • Product descriptionNecrosulfonamide
  • Packaging50mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number60598
  • Product descriptionNecrosulfonamide
  • Packaging1mg
  • Price$620
  • Updated2021-12-16
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number60598
  • Product descriptionNecrosulfonamide
  • Packaging10mg
  • Price$750
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number480073
  • Product descriptionMLKL Inhibitor, Necrosulfonamide - CAS 432531-71-0 - Calbiochem
    MLKL Inhibitor, Necrosulfonamide, CAS 432531-71-0, is a cell-permeable inhibitor that covalently modifies Cys88 and blocks human MLKL adaptor function.
  • Packaging25mg
  • Price$245
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberN388600
  • Product descriptionNecrosulfonamide
  • Packaging1mg
  • Price$140
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberN388600
  • Product descriptionNecrosulfonamide
  • Packaging100mg
  • Price$1390
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00DEZZ (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide 98+% 5mg $104 2021-12-16 Buy
aablocks AA00DEZZ (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide 98+% 10mg $147 2021-12-16 Buy
aablocks AA00DEZZ (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide 98+% 25mg $222 2021-12-16 Buy
aablocks AA00DEZZ (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide 98+% 50mg $348 2021-12-16 Buy
CSNpharm CSN24728 Necrosulfonamide 50mg $200 2021-12-16 Buy
Medical Isotopes, Inc. 60598 Necrosulfonamide 1mg $620 2021-12-16 Buy
Medical Isotopes, Inc. 60598 Necrosulfonamide 10mg $750 2021-12-16 Buy
Sigma-Aldrich 480073 MLKL Inhibitor, Necrosulfonamide - CAS 432531-71-0 - Calbiochem
MLKL Inhibitor, Necrosulfonamide, CAS 432531-71-0, is a cell-permeable inhibitor that covalently modifies Cys88 and blocks human MLKL adaptor function. 		25mg $245 2024-03-01 Buy
TRC N388600 Necrosulfonamide 1mg $140 2021-12-16 Buy
TRC N388600 Necrosulfonamide 100mg $1390 2021-12-16 Buy

Properties

storage temp. :+2C to +8C
solubility :DMSO:100.0(Max Conc. mg/mL);216.7(Max Conc. mM)
form :Dark yellow solid
color :Light yellow to yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway.

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