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ChemicalBook >> CAS DataBase List >> N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide price.
  • $45 - $1647
  • Product name: N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
  • CAS: 211311-95-4
  • MF: C19H22N2O2S
  • MW: 342.46
  • EINECS:
  • MDL Number:MFCD07364003
  • Synonyms:N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide;LY404187;N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonaMide;N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide;N-2-(4-(4-Cyanophenyl)phenyl)propyl-2-propanesulfonamide;LY-404187 N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide;CS-2739;100775
23 prices
Selected condition：
Brand
  • AK Scientific
  • Alichem
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • Crysdot
  • CSNpharm
  • Matrix Scientific
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 5mg
  • 1mg
  • 50
  • 10MG
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number0790AB
  • Product descriptionN-(2-(4''-Cyano-[1,1''-biphenyl]-4-yl)propyl)propane-2-sulfonamide
  • Packaging100mg
  • Price$583
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number211311954
  • Product descriptionN-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide
  • Packaging100mg
  • Price$426.6
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number211311954
  • Product descriptionN-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide
  • Packaging250mg
  • Price$619.36
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number211311954
  • Product descriptionN-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide
  • Packaging1g
  • Price$1595.8
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0019027
  • Product descriptionLY-404187 95.00%
  • Packaging10MG
  • Price$240.45
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number28741
  • Product descriptionLY404187
  • Packaging5mg
  • Price$110
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number28741
  • Product descriptionLY404187
  • Packaging10mg
  • Price$175
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number28741
  • Product descriptionLY404187
  • Packaging25mg
  • Price$352
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number28741
  • Product descriptionLY404187
  • Packaging50mg
  • Price$542
  • Updated2024-03-01
  • Buy
  • ManufacturerCrysdot
  • Product numberCD12096637
  • Product descriptionN-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide 97%
  • Packaging100mg
  • Price$391
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD12096637
  • Product descriptionN-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide 97%
  • Packaging250mg
  • Price$626
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD12096637
  • Product descriptionN-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide 97%
  • Packaging1g
  • Price$1565
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN22957
  • Product descriptionLY404187
  • Packaging5mg
  • Price$88
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN22957
  • Product descriptionLY404187
  • Packaging25mg
  • Price$335
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN22957
  • Product descriptionLY404187
  • Packaging50mg
  • Price$636
  • Updated2021-12-16
  • Buy
  • ManufacturerMatrix Scientific
  • Product number090059
  • Product descriptionN-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide 95+%
  • Packaging250mg
  • Price$742
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 0790AB N-(2-(4''-Cyano-[1,1''-biphenyl]-4-yl)propyl)propane-2-sulfonamide 100mg $583 2021-12-16 Buy
Alichem 211311954 N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide 100mg $426.6 2021-12-16 Buy
Alichem 211311954 N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide 250mg $619.36 2021-12-16 Buy
Alichem 211311954 N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide 1g $1595.8 2021-12-16 Buy
American Custom Chemicals Corporation API0019027 LY-404187 95.00% 10MG $240.45 2021-12-16 Buy
Cayman Chemical 28741 LY404187 5mg $110 2024-03-01 Buy
Cayman Chemical 28741 LY404187 10mg $175 2024-03-01 Buy
Cayman Chemical 28741 LY404187 25mg $352 2024-03-01 Buy
Cayman Chemical 28741 LY404187 50mg $542 2024-03-01 Buy
Crysdot CD12096637 N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide 97% 100mg $391 2021-12-16 Buy
Crysdot CD12096637 N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide 97% 250mg $626 2021-12-16 Buy
Crysdot CD12096637 N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide 97% 1g $1565 2021-12-16 Buy
CSNpharm CSN22957 LY404187 5mg $88 2021-12-16 Buy
CSNpharm CSN22957 LY404187 25mg $335 2021-12-16 Buy
CSNpharm CSN22957 LY404187 50mg $636 2021-12-16 Buy
Matrix Scientific 090059 N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide 95+% 250mg $742 2021-12-16 Buy

Properties

Boiling point :519.0±60.0 °C(Predicted)
Density :1.19±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
solubility :DMF: 15mg/mL; DMSO: 15mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL; Ethanol: 3mg/mL
form :A solid
pka :11.24±0.40(Predicted)
color :White to off-white

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

LY404187 is a benzothiadiazide positive allosteric modulator of AMPA receptors. It increases glutamate-induced activation of GluR1i, -2i, -2o, -3i, and -4i subunit-containing AMPA receptors with EC50 values of 5.65, 0.15, 1.44, 1.66, and 0.21 μM, respectively, in a calcium influx assay. LY404187 is selective for these AMPA receptors over GluR6 subunit-containing kainate receptors at 10 μM. LY404187 increases currents induced by glutamate and AMPA in rat prefrontal cortex pyramidal neurons (EC50s = 1.3 and 1.2 μM, respectively) but not in AMPA-stimulated primary rat embryonic hippocampal or primary cerebellar Purkinje neurons. LY404187 prevents decreases in the number of dopaminergic neurons in the substantia nigra induced by MPTP and 6-OHDA in mouse and rat, respectively, models of Parkinson’s disease when administered at a dose of 0.5 mg/kg per day.