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ChemicalBook >> CAS DataBase List >> 1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide

1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide

1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide price.
  • $28 - $3136.5
  • Product name: 1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide
  • CAS: 1396772-26-1
  • MF: C32H37N5O3
  • MW: 539.67
  • EINECS:-0
  • MDL Number:MFCD25372029
  • Synonyms:EPZ005687;EPZ-005687;1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)ph;1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide;EPZ005687;1H-Indazole-4-carboxamide, 1-cyclopentyl-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-6-[4-(4-morpholinylmethyl)phenyl]-;1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide EPZ 005687;EPZ 005687 1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide;EPZ 00568
23 prices
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Brand
  • AK Scientific
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
Package
  • 1unit
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 1000mg
  • ManufacturerAK Scientific
  • Product numberSYN3050
  • Product descriptionEPZ005687
  • Packaging100mg
  • Price$570
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4171
  • Product descriptionEPZ005687
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4171
  • Product descriptionEPZ005687
  • Packaging5mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4171
  • Product descriptionEPZ005687
  • Packaging25mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180981
  • Product descriptionEPZ005687 >98%
  • Packaging100mg
  • Price$986
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180981
  • Product descriptionEPZ005687 >98%
  • Packaging250mg
  • Price$1802
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180981
  • Product descriptionEPZ005687 >98%
  • Packaging1000mg
  • Price$3136.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13966
  • Product descriptionEPZ005687 ≥98%
  • Packaging5mg
  • Price$86
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13966
  • Product descriptionEPZ005687 ≥98%
  • Packaging10mg
  • Price$152
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13966
  • Product descriptionEPZ005687 ≥98%
  • Packaging25mg
  • Price$336
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13966
  • Product descriptionEPZ005687 ≥98%
  • Packaging50mg
  • Price$588
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM150834
  • Product description1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide 98%
  • Packaging100mg
  • Price$858
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1215
  • Product descriptionEPZ005687 99.49%
  • Packaging5mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1215
  • Product descriptionEPZ005687 99.49%
  • Packaging10mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1215
  • Product descriptionEPZ005687 99.49%
  • Packaging50mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1215
  • Product descriptionEPZ005687 99.49%
  • Packaging100mg
  • Price$450
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN3050 EPZ005687 100mg $570 2021-12-16 Buy
ApexBio Technology A4171 EPZ005687 1unit $28 2021-12-16 Buy
ApexBio Technology A4171 EPZ005687 5mg $60 2021-12-16 Buy
ApexBio Technology A4171 EPZ005687 25mg $200 2021-12-16 Buy
Biorbyt Ltd orb180981 EPZ005687 >98% 100mg $986 2021-12-16 Buy
Biorbyt Ltd orb180981 EPZ005687 >98% 250mg $1802 2021-12-16 Buy
Biorbyt Ltd orb180981 EPZ005687 >98% 1000mg $3136.5 2021-12-16 Buy
Cayman Chemical 13966 EPZ005687 ≥98% 5mg $86 2024-03-01 Buy
Cayman Chemical 13966 EPZ005687 ≥98% 10mg $152 2024-03-01 Buy
Cayman Chemical 13966 EPZ005687 ≥98% 25mg $336 2024-03-01 Buy
Cayman Chemical 13966 EPZ005687 ≥98% 50mg $588 2024-03-01 Buy
Chemenu CM150834 1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide 98% 100mg $858 2021-12-16 Buy
ChemScene CS-1215 EPZ005687 99.49% 5mg $60 2021-12-16 Buy
ChemScene CS-1215 EPZ005687 99.49% 10mg $90 2021-12-16 Buy
ChemScene CS-1215 EPZ005687 99.49% 50mg $250 2021-12-16 Buy
ChemScene CS-1215 EPZ005687 99.49% 100mg $450 2021-12-16 Buy

Properties

Boiling point :797.9±60.0 °C(Predicted)
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in EtOH; insoluble in H2O; ≥3.86 mg/mL in DMSO
form :solid
pka :11.88±0.10(Predicted)
color :Off-white to yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

EPZ005687 is a potent, selective inhibitor of the lysine methyltranferase EZH2 (Ki = 24 nM), the enzymatic subunit of polycomb repressive complex 2 (PRC2). It acts competitively with the EZH2 substrate S-adenosylmethionine. EPZ005687 has greater than 500-fold selectivity against 15 other protein methyltransferases and has 50-fold selectivity against EZH1. It blocks trimethylation of the PRC2 target histone 3 lysine 27 (IC50 = 80 nM), decreasing the proliferation of lymphoma cells carrying mutant, but not wild-type, EZH2.

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