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ChemicalBook >> CAS DataBase List >> N,N-DIMETHYL-(3R,4AR,5S,6AS,10S,10AR,10BS)-5-(ACETYLOXY)-3-ETHENYLDODECAHYDRO-10,10B-DIHYDROXY-3,4A,7,7,10A-PENTAMETHYL-1-OXO-1H-NAPHTHO[2,1-B]PYRAN-6-YL ESTER B-ALANINE HYDROCHLORIDE

N,N-DIMETHYL-(3R,4AR,5S,6AS,10S,10AR,10BS)-5-(ACETYLOXY)-3-ETHENYLDODECAHYDRO-10,10B-DIHYDROXY-3,4A,7,7,10A-PENTAMETHYL-1-OXO-1H-NAPHTHO[2,1-B]PYRAN-6-YL ESTER B-ALANINE HYDROCHLORIDE

N,N-DIMETHYL-(3R,4AR,5S,6AS,10S,10AR,10BS)-5-(ACETYLOXY)-3-ETHENYLDODECAHYDRO-10,10B-DIHYDROXY-3,4A,7,7,10A-PENTAMETHYL-1-OXO-1H-NAPHTHO[2,1-B]PYRAN-6-YL ESTER B-ALANINE HYDROCHLORIDE price.
  • $32 - $915
  • Product name: N,N-DIMETHYL-(3R,4AR,5S,6AS,10S,10AR,10BS)-5-(ACETYLOXY)-3-ETHENYLDODECAHYDRO-10,10B-DIHYDROXY-3,4A,7,7,10A-PENTAMETHYL-1-OXO-1H-NAPHTHO[2,1-B]PYRAN-6-YL ESTER B-ALANINE HYDROCHLORIDE
  • CAS: 138605-00-2
  • MF: C27H44ClNO8
  • MW: 546.1
  • EINECS:
  • MDL Number:MFCD00236421
  • Synonyms:N,N-DIMETHYL-(3R,4AR,5S,6AS,10S,10AR,10BS)-5-(ACETYLOXY)-3-ETHENYLDODECAHYDRO-10,10B-DIHYDROXY-3,4A,7,7,10A-PENTAMETHYL-1-OXO-1H-NAPHTHO[2,1-B]PYRAN-6-YL ESTER B-ALANINE HYDROCHLORIDE;NKH 477;(3r-(3-alpha,4a-beta,5-beta,6-beta,6a-alpha,10-alpha,10a-beta,10b-alpha))-id ;N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester b-Alanine hydrochloride;Forskolin, NKH477 ;beta-alanine,n,n-dimethyl-,5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydrox ;colforsindapropatehydrochloride ;N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester beta-alanine hydrochloride
15 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 50
  • 1MG
  • 5mg
  • 10mg
  • 25mg
  • 10
  • 50mg
  • ManufacturerAK Scientific
  • Product numberX3860
  • Product descriptionNKH 477
  • Packaging5mg
  • Price$202
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0015171
  • Product descriptionCOLFORSIN DAROPATE HYDROCHLORIDE 95.00%
  • Packaging5MG
  • Price$496.25
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0015171
  • Product descriptionCOLFORSIN DAROPATE HYDROCHLORIDE 95.00%
  • Packaging1MG
  • Price$128.1
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6802
  • Product descriptionNKH 477
  • Packaging1mg
  • Price$197
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11214
  • Product descriptionNKH477 (hydrochloride) ≥95%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11214
  • Product descriptionNKH477 (hydrochloride) ≥95%
  • Packaging5mg
  • Price$109
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11214
  • Product descriptionNKH477 (hydrochloride) ≥95%
  • Packaging10mg
  • Price$184
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0025284
  • Product descriptionNKH 477 ≥99.0%
  • Packaging5mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0025284
  • Product descriptionNKH 477 ≥99.0%
  • Packaging50mg
  • Price$650
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberN3290
  • Product descriptionNKH 477 ≥98% (HPLC), powder
  • Packaging5mg
  • Price$147
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberN3290
  • Product descriptionNKH 477 ≥98% (HPLC), powder
  • Packaging25mg
  • Price$581
  • Updated2024-03-01
  • Buy
  • ManufacturerTocris
  • Product number1603
  • Product descriptionNKH 477 ≥98%(HPLC)
  • Packaging10
  • Price$219
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number1603
  • Product descriptionNKH 477 ≥98%(HPLC)
  • Packaging50
  • Price$915
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberN605000
  • Product descriptionNKH 477
  • Packaging50mg
  • Price$865
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number256002
  • Product descriptionNKH 477
  • Packaging10mg
  • Price$502
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X3860 NKH 477 5mg $202 2021-12-16 Buy
American Custom Chemicals Corporation API0015171 COLFORSIN DAROPATE HYDROCHLORIDE 95.00% 5MG $496.25 2021-12-16 Buy
American Custom Chemicals Corporation API0015171 COLFORSIN DAROPATE HYDROCHLORIDE 95.00% 1MG $128.1 2021-12-16 Buy
ApexBio Technology B6802 NKH 477 1mg $197 2021-12-16 Buy
Cayman Chemical 11214 NKH477 (hydrochloride) ≥95% 1mg $32 2024-03-01 Buy
Cayman Chemical 11214 NKH477 (hydrochloride) ≥95% 5mg $109 2024-03-01 Buy
Cayman Chemical 11214 NKH477 (hydrochloride) ≥95% 10mg $184 2024-03-01 Buy
ChemScene CS-0025284 NKH 477 ≥99.0% 5mg $100 2021-12-16 Buy
ChemScene CS-0025284 NKH 477 ≥99.0% 50mg $650 2021-12-16 Buy
Sigma-Aldrich N3290 NKH 477 ≥98% (HPLC), powder 5mg $147 2024-03-01 Buy
Sigma-Aldrich N3290 NKH 477 ≥98% (HPLC), powder 25mg $581 2024-03-01 Buy
Tocris 1603 NKH 477 ≥98%(HPLC) 10 $219 2021-12-16 Buy
Tocris 1603 NKH 477 ≥98%(HPLC) 50 $915 2021-12-16 Buy
TRC N605000 NKH 477 50mg $865 2021-12-16 Buy
Usbiological 256002 NKH 477 10mg $502 2021-12-16 Buy

Properties

storage temp. :2-8°C
solubility :H2O: soluble3mg/mL, clear to slightly hazy (warmed)
form :White solid
color :white to beige
Water Solubility :Soluble to 40 mM in water

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Forskolin is a potent activator of adenylyl cyclase, but it is sparingly soluble in aqueous solutions. NKH477 is a water-soluble analog of forskolin which has both inotropic and vasodilator effects when administered intravenously. Like forskolin, NKH477 activates adenylyl cyclases without altering the activity of phosphodiesterases or sodium/potassium ATPases. This compound stimulates cardiac (type V) adenylyl cyclase more potently than other isoforms. NKH477 relaxes guinea pig tracheal smooth muscle precontracted with histamine with an EC50 value of 32.6 nM.

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