N-Methylolacrylamide
Product identifier
- Product name: N-Methylolacrylamide
- CBnumber: CB3182194
- CAS: 924-42-5
- EINECS Number: 213-103-2
- Synonyms: N-Methylolacrylamide,N-(hydroxymethyl)acrylamide
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
Classification of the substance or mixture
Acute toxicity - Category 3, Oral
Skin sensitization, Category 1
Germ cell mutagenicity, Category 1B
Carcinogenicity, Category 1B
Reproductive toxicity, Category 2
Specific target organ toxicity – repeated exposure, Category 1
Label elements
Pictogram(s)
- Signal wordDanger
H301 Toxic if swalloed
H302 Harmful if swallowed
H317 May cause an allergic skin reaction
H320 Causes eye irritation
H340 May cause genetic defects
H350 May cause cancer
H360 May damage fertility or the unborn child
H361 Suspected of damaging fertility or the unborn child
H371 May cause damage to organs
H372 Causes damage to organs through prolonged or repeated exposure
H373 May cause damage to organs through prolonged or repeated exposure
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P203 Obtain, read and follow all safety instructions before use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P333+P317 If skin irritation or rash occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P318 IF exposed or concerned, get medical advice.
P319 Get medical help if you feel unwell.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards
no data available
Substance
- Product name: N-Methylolacrylamide
- Synonyms: N-Methylolacrylamide,N-(hydroxymethyl)acrylamide
- CAS: 924-42-5
- EC number: 213-103-2
- MF: C4H7NO2
- MW: 101.1
Description of first aid measures
If inhaledFresh air, rest.
Remove contaminated clothes. Rinse and then wash skin with water and soap.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .
Most important symptoms and effects, both acute and delayed
SYMPTOMS: Symptoms of exposure to this compound include irritation of the eyes, skin, mucous membranes and upper respiratory tract. Compounds of this class cause peripheral neuropathies, paresthesias, weakness in lower limbs and bluish, sweaty cold hands with erythema and peeling of the palms. ACUTE/CHRONIC HAZARDS: The vapor or mist of this compound is irritating to the skin, eyes, mucous membranes and upper respiratory tract. In aqueous solution, this compound is readily absorbed through the skin. When heated to decomposition it emits toxic fumes of carbon dioxide, carbon monoxide and nitrogen oxides. (NTP, 1992)
Indication of any immediate medical attention and special treatment needed
Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist respirations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary . Monitor for shock and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Activated charcoal is not effective . Do not attempt to neutralize because of exothermic reaction. Cover skin burns with dry, sterile dressings after decontamination . Organic acids and related compounds
Extinguishing media
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
Specific Hazards Arising from the Chemical
Literature sources indicate that this chemical is nonflammable. (NTP, 1992)
Advice for firefighters
Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.
NFPA 704
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 0 | Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from acids. Store only if stabilized. Store in an area without drain or sewer access.
Control parameters
Occupational Exposure limit valuesno data available
no data available
Exposure controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures
Eye/face protectionWear safety goggles or eye protection in combination with breathing protection.
Protective gloves.
Use local exhaust or breathing protection.
no data available
Information on basic physicochemical properties
- Physical stateSolid
- ColourWhite to Off-White
- Odour
no data available
- Melting point/freezing point
5°C(lit.)
- Boiling point or initial boiling point and boiling range
277°C(lit.)
- Flammability
Combustible.
- Lower and upper explosion limit/flammability limit
no data available
- Flash point
>93°C
- Auto-ignition temperature
no data available
- Decomposition temperature
no data available
- pH6.0-7.0 (H2O, 20°C)
- Kinematic viscosity
no data available
- SolubilityChloroform (Slightly), Methanol (Slightly)
- Partition coefficient n-octanol/water
-1.81 (calculated)
- Vapour pressure31 hPa (25 °C)
- Density and/or relative density1.074
- Relative vapour density1.074
- Particle characteristics
no data available
Reactivity
The substance may polymerize due to heating and under the influence of acids. Decomposes on burning. This produces toxic fumes including nitrogen oxides.
Chemical stability
May undergo spontaneous combustion in storage.
Possibility of hazardous reactions
AMONG 4 FIBER DRUMS OF THIS CHEMICAL /N-HYDROXYMETHYLACRYLAMIDE/, 2 OF WHICH HAD NEVER BEEN OPENED, EXCESSIVE HEAT, SMOKE, CRACKLING & SMALL FLAME WERE NOTED. VERY SMALL AMOUNTS OF CONTAMINANT ARE BELIEVED TO HAVE CATALYZED THIS POLYMERIZATION REACTION, BUT STORAGE IN EXCESSIVELY HEATED AREAS CAN ALSO START THE REACTION.N-METHYLOLACRYLAMIDE may be sensitive to prolonged exposure to light. Polymerization and generation of heat and flames may occur on exposure to to heat or contaminants. Incompatible with strong oxidizers. (NTP, 1992)
Conditions to avoid
no data available
Incompatible materials
Excessive heat, smoke, flames, and cracking noise were emitted from stored fibre drums of the monomer, some unopened. Polymerization may have been initiated by minor contaminants (perhaps as vapors), and/or by excessively warm storage conditions.
Hazardous decomposition products
When heated to decomposition it emits toxic fumes of /nitrogen oxides/.
Acute toxicity
- Oral: LD50 Rat oral 474 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is mildly irritating to the eyes and skin. The substance may cause effects on the nervous system.
STOT-repeated exposure
The substance may have effects on the peripheral nervous system. Animal tests show that this substance possibly causes toxicity to human reproduction or development.
Aspiration hazard
A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered.
Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Other adverse effects
no data available
Disposal methods
ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
UN Number
ADR/RID: no data available
IMDG: no data available
IATA: no data available
UN Proper Shipping Name
ADR/RID: no data available
IMDG: no data available
IATA: no data available
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: III (For reference only, please check.)
IMDG: III (For reference only, please check.)
IATA: III (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
Safety, health and environmental regulations specific for the product in question
European Inventory of Existing Commercial Chemical Substances (EINECS)Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
An added stabilizer or inhibitor can influence the toxicological properties of this substance, consult an expert.
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.