2-Methyl-4-isothiazolin-3-one
Product identifier
- Product name: 2-Methyl-4-isothiazolin-3-one
- CBnumber: CB0193926
- CAS: 2682-20-4
- EINECS Number: 220-239-6
- Synonyms: Methylisothiazolinone,2-Methyl-4-isothiazolin-3-one
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
Substance
- Product name: 2-Methyl-4-isothiazolin-3-one
- Synonyms: Methylisothiazolinone,2-Methyl-4-isothiazolin-3-one
- CAS: 2682-20-4
- EC number: 220-239-6
- MF: C4H5NOS
- MW: 115.15
Description of first aid measures
General adviceMost important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
Extinguishing media
Suitable extinguishing mediaSpecial hazards arising from the substance or mixture
Carbon oxides Nitrogen oxides (NOx) Sulfur oxides Combustible.
Development of hazardous combustion gases or vapours possible in the event of fire.
Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Further information
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Personal precautions, protective equipment and emergency procedures
For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid generation of dusts.
Reference to other sections
For disposal see section 13.
Precautions for safe handling
Advice on safe handling
Work under hood. Do not inhale substance/mixture.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons.
Air sensitive. Store under inert gas.
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
control parameter
Hazard composition and occupational exposure limitsExposure controls
Personal protective equipmentUse equipment for eye protection tested and approved under appropriate
government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Acid-resistant protective clothing
Where risk assessment shows air-purifying respirators are appropriate use a full- face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Do not let product enter drains.
Information on basic physicochemical properties
- Appearancedark yellow Powder with lumps
- OdourNo data available
- Odour ThresholdNo data available
- pH2,58 at 50 g/l at 25 °C - OCSPP 830.7000
- Melting point/freezing pointMelting point/range: 46,7 - 48,3 °C - Regulation (EC) No. 440/2008, Annex, A.1
- Initial boiling point and boiling range >130 °C at 16 hPa - Regulation (EC) No. 440/2008, Annex, A.2
- Flash pointNot applicable
- Evaporation rateNo data available
- Flammability (solid, gas)No data available
- Upper/lower flammability or explosive limitsNo data available
- Vapour pressure 0,0099 hPa at 20 °C - Regulation (EC) No. 440/2008, Annex, A.4
- Vapour density No data available
- Relative density1,39 g/cm3 at 20 °C 1,39 at 20 °C - Regulation (EC) No. 440/2008, Annex, A.3
- Water solubilitysoluble
- Partition coefficient: n-octanol/waterlog Pow: -0,34 at 30 °C - OECD Test Guideline 117 - Bioaccumulation is not expected.
- Autoignition temperature 396 °C at 1.012 hPa
- Decomposition temperature No data available
- ViscosityViscosity, kinematic: No data available Viscosity, dynamic: No data available
- Explosive propertiesNo data available
- Oxidizing propertiesNo data available
Other safety information
Surface tension 68,8 mN/m at 1g/l at 19,5 °C
-
OECD Test Guideline 115
Dissociation constant > 2,81 at 21 °C
-
OECD Test Guideline 112
Reactivity
The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.
Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) . Stable under recommended storage conditions.
Possibility of hazardous reactions
No data available
Conditions to avoid
no information available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
In the event of fire: see section 5
Information on toxicological effects
Acute toxicity(OECD Test Guideline 401)
LC50 Inhalation - Rat - male and female - 4 h - 0,11 mg/l (OECD Test Guideline 403)
LD50 Dermal - Rat - male and female - 242 mg/kg (OECD Test Guideline 402)
Result: Causes burns. (OECD Test Guideline 404)
Remarks: Causes serious eye damage.
(OECD Test Guideline 406)
Local lymph node assay (LLNA) - Mouse Result: positive
(OECD Test Guideline 429) Maximization Test - Guinea pig Result: positive
(OECD Test Guideline 406)
Test system: S. typhimurium
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471
Result: negative
Test Type: Chromosome aberration test in vitro Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 473
Result: negative
Test Type: In vitro mammalian cell gene mutation test Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 476
Result: negative
Test Type: Chromosome aberration test in vitro Test system: Human lymphocytes
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 473
Result: negative
Test Type: unscheduled DNA synthesis assay Species: Rat
Application Route: Oral
Method: OECD Test Guideline 486
Toxicity
(OECD Test Guideline 203)
flow-through test EC50 - Daphnia magna (Water flea) - 0,85 mg/l - 48 h
(OECD Test Guideline 202)
Persistence and degradability
Biodegradability Result: 55,8 % - Not readily biodegradable.
(OECD Test Guideline 301B)
Remarks: The 10 day time window criterion is not fulfilled.
Bioaccumulative potential
Bioaccumulation Lepomis macrochirus - 56 d
(2-Methyl-4-isothiazolin-3-one)
Bioconcentration factor (BCF): 5,75 Lepomis macrochirus - 56 d
(2-Methyl-4-isothiazolin-3-one)
Bioconcentration factor (BCF): 48,1
Mobility in soil
No data available
Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Other adverse effects
No data available
Waste treatment methods
Product
See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.
UN number
ADR/RID: 3261 IMDG: 3261 IATA: 3261
UN proper shipping name
ADR/RID: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S. (2-Methyl-4-isothiazolin-3-one) IMDG: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S. (2-Methyl-4-isothiazolin-3-one)
IATA: Corrosive solid, acidic, organic, n.o.s. (2-Methyl-4-isothiazolin-3-one)
Transport hazard class(es)
ADR/RID: 8 IMDG: 8 IATA: 8
Packaging group
ADR/RID: II IMDG: II IATA: II
Environmental hazards
ADR/RID: yes IMDG Marine pollutant: yes IATA: no
Special precautions for user
No data available
Safety, health and environmental regulations/legislation specific for the substance or mixture
Regulations on the Safety Management of Hazardous ChemicalsAbbreviations and acronyms
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- CAS: Chemical Abstracts Service
- EC50: Effective Concentration 50%
- IATA: International Air Transportation Association
- IMDG: International Maritime Dangerous Goods
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- STEL: Short term exposure limit
- TWA: Time Weighted Average
References
【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/
【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.