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European Journal of Medicinal Chemistry

European Journal of Medicinal Chemistry

IF: 6
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Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives

Published:1 July 2009 DOI: 10.1016/j.ejmech.2008.07.012 PMID: 18760508
Zahra Rezaei , Soghra Khabnadideh , Keyvan Pakshir , Zahra Hossaini , Fatemeh Amiri , Elham Assadpour

Abstract

This study describes the design, synthesis and evaluation of a novel series of 1,2,4-triazole and benzotriazole derivatives as inhibitors of cytochrome P450 14α-demethylase (14DM). The chemical structures of the new compounds were confirmed by elemental and spectral (1H NMR, 13C NMR, Mass) analyses. Compounds were designed by a generating virtual library of compounds and docking them into the enzyme active site. Furthermore, they were found to have in vitro activity against Microsporum canis, Trichophyton mentagrophyte, Trichophyton rubrum, Epidermophyton floccosum, and Candida albicans comparable to fluconazole and clotrimazole.

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