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Chemical Engineering Journal

Chemical Engineering Journal

IF: 13.3
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Tea leaf-derived nanovesicles for ferric-supply-amplified ICD and macrophage reprogramming to boost immunotherapy against head and neck squamous carcinoma

Published:9 December 2024 DOI: 10.1016/j.cej.2024.158469
Hanzhe Liu, Zhenan Liu, Weilian Liang, Hokeung Tang, Lili Yu, Tong Wang, Lan Liu, Qingli Chen, Jia-Wei Wang, Xian-Zheng Zhang, Guo-Feng Luo, Zhengjun Shang

Abstract

Combination of multiple immune activation pathways that can modulate different immune axes in coordination has been found extremely effective in amplifying immunotherapy. In this study, by using a naturally occurring tea leaf-derived nanovesicles (TDNVs), we prepare an all-in-one multifunctional immunotherapeutic nanomedicine (denoted as DFeTNVs) by co-loading chemotherapeutic drug doxorubicin (DOX) into a ferric-engineered TDNVs. Owing to the acid-triggered responsiveness, the loaded cargoes (DOX and Fe3+) would be released in the tumor acidic microenvironment to elicit DOX-mediated immunogenic cell death (ICD) that is further enhanced by the ferric ions-mediated Fenton reaction. Strikingly, the inherent surface galactose of DFeTNVs could promote specific cellular uptake of macrophages through galactose-type lectin-mediated endocytosis, so as to deliver Fe3+ inside macrophages for potentiating the polarization of M2-like tumor-associated macrophages (TAMs) into M1 phenotype, thereby boosting the macrophage-mediated phagocytosis and T cell activation. All these contribute to evoke a strong anticancer immune response, especially in combination with anti-PD-L1 antibody, to inhibit tumor growth. The present work provides a delicate design integrated with multiple functions (i.e., drug loading, metal chelation, intrinsic targeting) without using excessive chemical ligands or complex synthetic processes, promising the feasibility of this immunotherapeutic nanosystem for future clinical applications.

Substances (5)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Doxorubicin hydrochloride 25316-40-9 C27H29NO11.ClH 789 suppliers $20.00-$2052.00
(-)-Epicatechin gallate 1257-08-5 C22H18O10 404 suppliers $28.00-$1963.50
Deoxyribonuclease 9003-98-9 NULL 290 suppliers $58.00-$2170.00
D-(+)-GALACTOSE 10257-28-0 C6H12O6 80 suppliers $138.00-$490.00
FETUIN 9014-81-7 NULL 67 suppliers $37.07-$4380.00

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