成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook >> journal list >> International Journal of Biological Macromolecules >>article
International Journal of Biological Macromolecules

International Journal of Biological Macromolecules

IF: 7.7
Download PDF

Low-dose IL-2 restores metabolic dysfunction and immune dysregulation in mice with type 2 diabetes induced by a high-fat, high-sugar diet and streptozotocin

Published:6 December 2024 DOI: 10.1016/j.ijbiomac.2024.138468 PMID: 39647763
Lijing Huo,?Hairui Zhang,?Shiyu Hou,?Wenting Li,?Qingwen Meng,?Chenhui Li,?Xiaohan Ma,?Lijing Huang,?Jintian He,?Baohua Zhao

Abstract

Interleukin-2 (IL-2) is pivotal in immune regulation, particularly in the promotion of regulatory T (Treg) cells and the maintenance of immune tolerance. While its efficacy in autoimmune diseases is well established, its role in type 2 diabetes (T2D) remains largely unexplored. This study investigates the effects of low-dose IL-2 in a KM mouse model of T2D induced by streptozotocin (STZ) and a high-fat, high-sugar (HFHS) diet. We found that low-dose IL-2 administration significantly improved fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c) levels, and glucose tolerance, indicating better glycemic control. Additionally, IL-2 treatment improved insulin sensitivity, enhanced insulin secretion, and ameliorated lipid metabolism, as evidenced by reduced cholesterol and triglyceride levels. These metabolic improvements were associated with a modulation of inflammation, including a reduction in pro-inflammatory cytokines (TNF-α, IL-1β) and an increase in anti-inflammatory cytokines (IL-10). Importantly, IL-2 also altered the gut microbiome, reducing intestinal inflammation and endotoxin levels, which suggests a broader impact on metabolic health beyond immune regulation. These findings support the potential of low-dose IL-2 as an immunotherapeutic approach for improving metabolic dysfunction and inflammation in T2D.

Substances (1)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Streptozotocin 18883-66-4 C8H15N3O7 428 suppliers $25.00-$1610.00

Similar articles

IF:5.6

AICAR Improves Outcomes of Metabolic Syndrome and Type 2 Diabetes Induced by High-Fat Diet in C57Bl/6 Male Mice.

International Journal of Molecular Sciences Elena A Tukhovskaya, Elvira R Shaykhutdinova,etc Published: 11 December 2022
IF:1.7

Raspberry ketone attenuates high-fat diet-induced obesity by improving metabolic homeostasis in rats

Asian Pacific journal of tropical biomedicine A. Alkaladi,?H. Ali,etc Published: 1 January 2020
IF:13

Dapagliflozin: A Review in Type 2 Diabetes.

Drugs Sohita Dhillon,etc Published: 1 July 2019