成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook >> journal list >> International Journal of Biological Macromolecules >>article
International Journal of Biological Macromolecules

International Journal of Biological Macromolecules

IF: 7.7
Download PDF

Catechol-grafted chitosan-based antioxidant hydrogel with rapid self-healing property for wound healing

Published:6 December 2024 DOI: 10.1016/j.ijbiomac.2024.138509 PMID: 39647754
Yajie Zhong,?Libin Dong,?Jiao Li,?Farzad Seidi,?Guofu Li,?Huining Xiao

Abstract

Chronic wounds, particularly those with non-healing ulcers, show high levels of oxidant stress, such as excessive reactive oxygen species (ROS), which delays the healing process. Bacterial infections in wounds increase the need for antibiotics, which brings up serious concerns regarding antibiotic resistance. The innovative antibiotic-free strategies to endow the hydrogels with antibacterial and antioxidant features including the grafting of ROS-scavenging moieties onto the hydrogel structure are in high demand for wound management. Herein, an antibacterial and antioxidant hydrogel with rapid self-healing performance was fabricated via the dynamic borate ester cross-linkages between catechol-grafted chitosan (CS-CA) and polyvinyl alcohol in the presence of borax with the incorporation of ellagic acid (EA). Benefiting from the catechol groups from EA and CS-CA, the resulting hydrogel exhibited desirable adhesive property, excellent antioxidant and intensified antibacterial dual functions. Furthermore, the hydrogel demonstrated remarkable biocompatibility and pH-responsive behavior for the controlled release of EA, attributed to the reversible characteristics of borate ester linkages. Notably, these multifunctional hydrogels exhibited substantial regenerative capabilities in wound healing, as evidenced by in vivo assessments conducted on a full-thickness skin defect model, highlighting their considerable potential as wound dressings for effective wound management.

Substances (2)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Chitosan 9012-76-4 C6H11NO4X2 859 suppliers $14.00-$1125.56
Sorbitol 50-70-4 C6H14O6 830 suppliers $5.00-$2150.00

Similar articles

IF:10.7

Antibacterial betaine modified chitosan-based hydrogel with angiogenic property for photothermal enhanced diabetic wound repairing

Carbohydrate Polymers Kaiyue Zhang, Jingjing Zhu,etc Published: 19 November 2024
IF:15.5

Glycoengineered extracellular vesicles released from antibacterial hydrogel facilitate diabetic wound healing by promoting angiogenesis

Journal of Extracellular Vesicles Kewei Wang, Qin He,etc Published: 27 November 2024
IF:2.3

An alginate-Based tube gel delivering 2-deoxy-D-ribose for stimulation of wound healing.

Journal of Biomaterials Applications Safina Abid, Saima Zulfiqar,etc Published: 1 August 2023