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International Journal of Biological Macromolecules

International Journal of Biological Macromolecules

IF: 7.7
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Oral chitosan-cyclodextrin “shell-core” nanoparticles co-loaded Rhein and chlorogenic acid for ulcerative colitis treatment

Published:6 December 2024 DOI: 10.1016/j.ijbiomac.2024.138493 PMID: 39647762
Wenbiao Nie,?Wenzhen Zhong,?Lin Qian,?Huiyun Zhong,?Yusen Hou,?Haiting Xu,?Shanshan Qi,?Linxin Dai,?Xiaoqin Han,?Xinyue Yang,?Runchun Xu,?Yao He,?Dasheng Lin,?Fei Gao

Abstract

The food-derived ingredients Rhein (RH) and chlorogenic acid (CGA) have DEMONSTRATED a potential synergistic effect in the treatment of ulcerative colitis (UC) through their anti-inflammatory and antioxidant properties. However, the oral co-delivery of RH and CGA faces challenges such as differences in hydrophilicity and hydrophobicity, gastrointestinal instability, and inadequate colonic targeting. To address these issues, shell-core nanoparticles were developed for the co-encapsulation of RH and CGA (CP@CGA-FA/TA@RH NPs). These nanoparticles utilize cyclodextrin-based polymers and folate-amantadine polymers to form a supramolecular core that targets macrophages for anti-inflammatory action with RH, while chitosan cross-link to CGA in the outer shell provides microenvironment-sensitive antioxidant release. The results indicate that CP@CGA-FA/TA@RH NPs could effectively inhibit the classical TLR4/MyD88/NF-κB-mediated anti-inflammatory pathway and activate the Nrf2/HO-1-mediated antioxidant pathway, offering a novel approach to UC treatment. Q-value analysis confirms the substantial co-medication effect between RH and CGA. This study is the first to develop a nano-system combining two food-derived ingredients for the integrated treatment of UC.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
4-Dimethylaminopyridine 1122-58-3 C7H10N2 1239 suppliers $6.00-$5370.00
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride 25952-53-8 C8H18ClN3 944 suppliers $9.00-$15216.00
Pectin 9000-69-5 C6H12O6 428 suppliers $13.50-$6898.73
Rhodium 7440-16-6 Rh 346 suppliers $57.00-$8350.00

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