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International Journal of Biological Macromolecules

International Journal of Biological Macromolecules

IF: 7.7
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Novel insights into Cntnap4 in Alzheimer's disease: Intestinal flora interaction

Published:6 December 2024 DOI: 10.1016/j.ijbiomac.2024.138508 PMID: 39647729
Xiaodan Xiao,?Yanfei Guan,?Huiyu Mo,?Kaizhao Lv,?Jiaxin Chen,?Jiaxing Xie,?Qiguang Meng,?Jianqi Liu,?Yongkeng Lu,?Feng Gao,?Qingzhuang Chen

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder with unclear etiology. This study employs single-cell RNA sequencing (scRNA-seq), high-throughput transcriptome sequencing, 16s rRNA sequencing, and animal experiments to investigate the role of the contactin-associated protein like-4 (Cntnap4) gene in AD and its interaction with intestinal flora. We found that Cntnap4 deficiency in AD mice led to increased Tau protein phosphorylation, amyloid-beta plaque accumulation, and neuronal loss. Astrocytes in Cntnap4-/- mice showed impaired amyloid-beta processing. 16?s rRNA sequencing revealed distinct intestinal flora compositions between Cntnap4-/- and control mice, indicating a potential link between gut microbiota and AD progression. Notably, GABA supplementation improved cognitive impairment, restored synaptic currents, reduced amyloid-beta plaques, and increased neuronal counts. This study highlights Cntnap4's critical role in AD and suggests gut-brain axis involvement, offering novel insights for potential therapeutic strategies.

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Procduct Name CAS Molecular Formula Supplier Price
Streptozotocin 18883-66-4 C8H15N3O7 428 suppliers $25.00-$1610.00

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