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Chemical Engineering Journal

Chemical Engineering Journal

IF: 13.3
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De Novo siRNA nanoplatform with NIR-II imaging for treatment of carotid atherosclerotic plaques

Published:9 December 2024 DOI: 10.1016/j.cej.2024.158455
Jialu Gao, Hua Zhu, Huanhuan Cai, Qihang Ding, Xiaoxing Xiong, Tong Zhang, Bo Chen, Wumei Wang, Xinpeng Ju, Jianying Huang, Xiaodong Zeng, Jong Seung Kim, Xuechuan Hong

Abstract

Reducing foam cell formation and accumulation within plaques is a critical strategy for treating atherosclerosis. Although current lipid-lowering therapies have significantly improved the management of atherosclerosis, the risk of cardiovascular events remains. Thus, it is necessary to explore next-generation therapies to reduce foam cell formation, inflammation, and oxidative stress. To address these challenges, we present an innovative near-infrared II (NIR-II) fluorescent dye coupled with a lesion-targeting peptide, forming a molecular self-assembly nanoplatform for effective in vitro small interfering RNA (siRNA) delivery. This platform downregulates Epsin1/2, a family of ubiquitin-binding endocytic adaptors, upregulates the expressions of ABCG1 and LRP-1 proteins, and markedly reduces foam cell formation. Additionally, this system enables real-time tracking of plaque accumulation, therapeutic response, and efficacy through in vivo noninvasive NIR-II imaging. Systemic siRNA delivery significantly suppresses lipid accumulation, plaque size, and necrotic core area in the carotid plaque model of ApoE?/? mice. These results suggest that this multi-functional nanoplatform could become an effective tool for NIR-II image-guided siRNA delivery for personalized treatment of atherosclerosis.

Substances (6)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Dimethyl sulfoxide 67-68-5 C2H6OS 1344 suppliers $15.00-$120900.00
Dichloromethane 75-09-2 CH2Cl2 1289 suppliers $8660.00
N,N-Dimethylformamide 68-12-2 C3H7NO 1214 suppliers $11.20-$12200.00
Polyethylene Glycol 25322-68-3 (C2H4O)nH2O 1135 suppliers $5.00-$3550.00
3,4-Dimethoxythiophene 51792-34-8 C6H8O2S 366 suppliers $6.00-$961.77
N-THIONYLANILINE 1122-83-4 C6H5NOS 102 suppliers $19.00-$1146.05

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