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International Journal of Biological Macromolecules

International Journal of Biological Macromolecules

IF: 7.7
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Sustainable lignin-based composite hydrogels for controlled drug release and self-healing in antimicrobial wound dressing

Published:5 December 2024 DOI: 10.1016/j.ijbiomac.2024.138327 PMID: 39638185
Zhu Shan,?Bo Jiang,?Peng Wang,?Wenjuan Wu,?Yongcan Jin

Abstract

Bacterial infections pose a significant threat to global public health, demanding innovative solutions in biomedical field. Lignin is a naturally abundant polyphenol-rich polymer, offer promising potential to fabricate advance biomaterials for biomedical applications. Hence, a composite hydrogel with antimicrobial and antioxidant activities based on the development of dynamic covalent bonds among sodium alginate, lignin and epigallocatechin-3-gallate (EGCG) was designed. Lignin provides structural integrity to hydrogel backbone as well as released synergistically with the drug. This synergistic effect of the pH-responsive controlled release of both EGCG and lignin improved the releasing ability and bioactivity of the hydrogels. In in vitro antimicrobial experiments, the addition of 3.08?wt% lignin significantly enhanced bactericidal efficacy against Escherichia coli and Staphylococcus aureus, raising the killing rate from 20?% to over 96?%. The dynamic borate bond allows hydrogel network to repair itself when it is disrupted. Its self-healing ability, pH-responsive drug delivery, biocompatibility and strong antimicrobial and antioxidant effects make it a promising candidate for chronic wound management. This lignin-based hydrogel marks a significant innovation in sustainable, multifunctional biomedical materials.

Substances (2)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Lithium bromide 7550-35-8 BrLi 640 suppliers $6.00-$2441.27
(-)-Epigallocatechin gallate 989-51-5 C22H18O11 597 suppliers $8.00-$1472.63

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